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Table 2 WHO 1998 criteria for diagnosis of sCJD

From: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito

Diagnostic Certainty

Characteristic

Definite

Diagnosed standard neuropathological techniques; and/or immunocytochemically

Probable

Progressive dementia

and at least two out of the following four clinical features

Myoclonus

Visual/cerebellar dysfunction

Pyramidal/Extrapyramidal symtoms

Akinetic mutism

And

Positive EEG

Or

Positive 14–3-3

Possible

Progressive dementia

None of 14–3-3 protein and EEG

and at least two out of the following four clinical features

Myoclonus

Visual/cerebellar dysfunction

Pyramidal/Extrapyramidal symtoms

Akinetic mutism

And

Duration less than 2 years

  1. EEG: electroencephalogram