From: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito
Diagnostic Certainty | Characteristic |
---|---|
Definite | Diagnosed standard neuropathological techniques; and/or immunocytochemically |
Probable | Progressive dementia |
and at least two out of the following four clinical features | |
Myoclonus | |
Visual/cerebellar dysfunction | |
Pyramidal/Extrapyramidal symtoms | |
Akinetic mutism | |
And | |
Positive EEG | |
Or | |
Positive 14–3-3 | |
Possible | Progressive dementia |
None of 14–3-3 protein and EEG | |
and at least two out of the following four clinical features | |
Myoclonus | |
Visual/cerebellar dysfunction | |
Pyramidal/Extrapyramidal symtoms | |
Akinetic mutism | |
And | |
Duration less than 2 years |