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Table 3 The University of Edinburgh 2017 criteria for diagnosis of sCJD

From: Case series of Creutzfeldt-Jakob disease in a third-level hospital in Quito

Diagnostic Certainty

Characteristic

Definite

Progressive neurological syndrome AND Neuropathologically or immunocytochemically or biochemically confirmed

Probable

Rapidly progressive cognitive impairment

Two or more of A – B – C – D

And

Typical EEG (Generalised periodic complexes)

OR

Rapidly progressive cognitive impairment

Two or more of A – B – C – D

And

Typical MRI brain scan (High signal in caudate/putamen on MRI brain scan or at least two cortical regions temporal, parietal, occipital, either on DWI or FLAIR

OR

Rapidly progressive cognitive impairment

Two or more of A – B – C – D

And

Positive 14–3-3

OR

elaProgressive neurological syndrome and positive RT-QuIC in CSF or other tissues

Possible

Rapidly progressive cognitive impairment

two or more of A – B – C – D

And duration < 2 years

  1. Clinical Criteria
  2. A. Myoclonus
  3. B. Visual or cerebellar problems
  4. C. Pyramidal or extrapyramidal features
  5. D kinetic mutism
  6. EEG electroencephalogram, MRI magnetic resonance imaging, DWI diffusion-weighted imaging, FLAIR fluid attenuated inversion recovery, RT-QuIc positive real-time quaking-induced conversión, CSF cerebrospinal fluid