Axonal chronic injury in treatment-naïve HIV+ adults with asymptomatic neurocognitive impairment and its relationship with clinical variables and cognitive status

Table 3 Regression coefficients and significance for MD values and clinical variables and cognitive status scores

		MD values of HIV-associated white matter impairment
		GCC	BCC	SCC	ACR_R	ACR_L	SCR_R	SCR_L
Clinical Variables	Age	0.057	− 0.118	−0.096	0.221	0.26	0.239	0.016
	CD4	0.433	−0.282	− 0.637	0.986	− 0.724	−1.001	− 0.142
	CD4/CD8	− 0.101	− 0.331	0.331	− 0.437 ^**	− 0.274	− 0.127	− 0.307
	VL(log)	0.381^*	0.162	0.207	0.277	0.006	0.287	0.055
	DI	0.564	−0.281	−0.326	0.815	−0.8	−1.319	− 0.224
Cognitive Status	VF	−0.053	0.012	−0.169	−0.114	− 0.135	−0.293	− 0.459^*
	A/WM	0.021	−0.004	−0.238	0.21	−0.001	0.424	0.141
	EF	−0.272	−0.226	− 0.2	−0.172	− 0.133	−0.194	− 0.218
	M(LDR)	−0.417^**	−0.338	0.159	−0.511^**	− 0.559^**	−0.501^**	− 0.281
	SIP	0.684^**	0.427^*	0.155	0.559^**	0.583^**	0.444^**	0.239
	FM	−0.417^**	−0.259	−0.403^*	− 0.391^**	−0.321^*	− 0.474^**	−0.443^*

The regression coefficients and significance results were calculated by the multiple linear analysis method. MD mean diffusivity, GCC genu of corpus callosum, BCC body of corpus callosum, SCC splenium of corpus callosum, ACR anterior corona radiata, SCR superior corona radiata, L left, R right, VL viral load, DI duration of infection, VF Verbal Fluency, A/WM Attention/Working Memory, EF Executive Functioning, SIP Speed of Information Processing, MS Motor Skills, * P < 0.1, ** P < 0.05

ISSN: 1471-2377