Axonal chronic injury in treatment-naïve HIV+ adults with asymptomatic neurocognitive impairment and its relationship with clinical variables and cognitive status

Table 4 Regression coefficients and significance for AD values and clinical variables and cognitive status scores

		AD values of HIV-infected in different brain regions
		GCC	BCC	SCC	ACR_R	ACR_L	SCR_R	SCR_L	ALIC_R	ALIC_L	EC_R	EC_L	RIC_L	PCR_L	PTR_L	SS_L	SLF_L
Clinical Variables	Age	−0.321	−0.395	−0.446	−0.111	0.053	0.078	−0.202	−0.025	− 0.065	0.27	− 0.19	0.115	− 0.051	−0.006	− 0.251	−0.264
	CD4	0.475	−0.521	−0.416	2.242	0.978	−0.68	0.008	−0.644	0.082	0.645	1.852	0.841	0.18	−1.02	0.673	0.613
	CD4/CD8	0.108	−0.139	0.2	− 0.125	−0.185	0.242	0.126	0.717**	0.224	0.153	0.394	−0.366	−0.488**	− 0.372	−0.613	0.12
	VL(log)	0.404	0.445	0.164	0.201	−0.061	0.379	0.228	0.533**	0.579*	0.211	0.376	0.059	0.242	0.124	0.22	−0.083
	DI	0.547	−0.64	−0.088	2.21	0.848	−0.782	0.082	−0.672	−0.143	0.276	1.876	0.484	−0.167	−1.267	0.265	1.071
Cognitive Status	VF	−0.256	−0.333	− 0.194	−0.411	− 0.507**	−0.67**	− 0.502	0.196	− 0.671**	0.059	− 0.16	0.396	− 0.057	0.102	0.126	−0.437
	A/WM	0.237	0.238	−0.219	0.474	0.147	0.619**	0.461	0.201	0.566**	0.091	0.062	−0.078	0.245	−0.243	− 0.219	0.115
	EF	−0.278	−0.406*	− 0.385*	−0.305	0.045	−0.227	− 0.183	−0.394*	0.099	−0.406	− 0.251	−0.249	− 0.408*	−0.339*	− 0.24	0.394
	M(LDR)	0.011	−0.028	0.334	−0.148	−0.272	− 0.307	−0.132	0.245	0.079	0.067	0.134	−0.038	−0.272	− 0.074	0.116	0.068
	SIP	0.589**	0.382*	0.178	−0.049	0.206	0.136	0.176	0.631**	0.544**	0.082	−0.125	0.435	0.17	0.529**	0.362	0.123
	FM	−0.329	−0.447*	− 0.241	−0.179	− 0.268	−0.622**	− 0.441	0.081	− 0.232	−0.281	− 0.469	0.026	− 0.172	0.143	0.092	−0.406

The regression coefficients and significance results were calculated by the multiple linear analysis method. AD axial diffusivity, GCC genu of corpus callosum, BCC body of corpus callosum, SCC splenium of corpus callosum, ACR anterior corona radiata, SCR superior corona radiata, L left, R right, ALIC anterior limb of internal capsule, EC external capsule, RIC retrolenticular part of internal capsule, PCR posterior corona radiate, PTR posterior thalamic radiation, SS sagittal stratum, SLF superior longitudinal fasciculus, VL viral load, DI duration of infection, VF Verbal Fluency, A/WM Attention/Working Memory, EF Executive Functioning, SIP Speed of Information Processing, MS Motor Skills, * P < 0.1, ** P < 0.05

ISSN: 1471-2377