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Table 1 Reported cases describing the different phenotypes during various episodes

From: Anti-ganglioside complex antibody profiles in a recurrent complicated case of GQ1b-seronegative miller fisher syndrome and Bickerstaff brainstem encephalitis: a case report

Case Age Sex Episode Preceding illness DOC Ophthalm oplegia Ataxia Areflexia Hyper reflexia PR Limb weakness GQ1b Ab GSC Ab Phenotype FG at nadir Treatment Outcome Reference
1 38 F First URI + + + + n.e MFS 1 IAPP CR [8]
38 Second URI + + + n.e GBS 4 IAPP CR
2 10 F First URI + + + n.e n.e MFS 2 n.d CR [9]
17 Second n.d + + n.e n.e Incomplete MFS 1 n.d CR
19 Third Fever + + + + + ± + n.e BBE 5 IVIG NCR
3 48 M First n.d + n.d n.d n.d n.d + n.e n.e MFS-GBS 5 n.d CR [10]
53 Second + + + + + + n.e BBE-GBS 5 IVIG CR
4 35 M First n.d + n.d n.d n.d n.d n.e n.e Incomplete MFS 1 CR [11]
38 Second n.d + + + + n.e n.e BBE 5 IVIG CR
43 Third Fever + + + + n.e BBE 5 IVIG CR
5 46 M First n.d + + + + n.d n.e MFS (BBE)a 3 IVIG NCR [12]
46 Second n.d + + + + + ± n.e BBE 2 IVIG NCR
6 25 M First URI + + + + + MFS-GBS 4 IVIG CR Our case
28 Second URI + + + + + MFS-GBS 4 IVIG CR
33 Third URI + + + + + + + BBE-GBS 5 IVIG NCR
  1. F female, M male, GBS guillain-Barré syndrome, MFS miller fisher syndromes, BBE bickerstaff brainstem encephalitis, Incomplete FS acute ophthalmoparesis, acute ataxic neuropathy, acute ptosis and acute mydriasis, URI upper respiratory infection, DOC disturbance of consciousness, PR pathological reflex, Limb weakness + MMT ≤ 3 at least one limb, Limb weakness ± MMT ≥ 4, MFS-GBS MFS with definite limb weakness (MMT ≤ 3), BBE-GBS BBE with definite limb weakness (MMT ≤ 3), n.e not examined, n.d not documented, FG fuctional grade, IAPP immunoadsorption plasmapheresis, IVIG intravenous immunoglobulin, CR complete recovery, NCR near complete recovery (Mild diplopia, weakness, and atxia without disability)
  2. aAlthough this case was considered “Fisher-Bickerstaff syndrome” and the first episode was considered MFS in reference [9], we consider the first episode as BBE because of the presence of drowsiness [1]