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Fig. 1 | BMC Neurology

Fig. 1

From: Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Fig. 1

Effect of dapagliflozin on epileptiform activity on EEG as measured by spike percentage for PTZ–induced seizures in rats. When compared to the A2 arm in which no dapagliflozin (DGF) was administered, intraperitoneal (IP) dapagliflozin at 75 mg/kg and 150 mg/kg were able to significantly reduce mean EEG spike percentage by over 3 times, with p–value of < 0.0001, in rats treated with 35 mg/kg of IP pentylenetetrazol (PTZ). The ± range represents the standard deviation (SD) from the mean

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