Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Table 1 Additional parameters and results from the EEG experiments

Arm	Seizure onset (seconds)	Duration of single seizures (seconds)	Duration of high frequency or high amplitude spiking (seconds)	Total seizure duration (seconds)
A1	0 ± 0.0	0 ± 0.0	0 ± 0.0	0 ± 0.0
A2	45.08 ± 9.3	10.2 ± 3.10	5.3 ± 0.93	2564.2 ± 105.6
A3	110.3 ± 16.8**	6.06 ± 1.08*	3.2 ± 0.85*	685.2 ± 60.8**
A4	185.7 ± 12.1**	2.1 ± 0.93*	0.8 ± 0.12*	451.8 ± 35.9**

The treatment arms are as follows: A1 for saline (control arm), A2 for PTZ at 70 mg/kg and saline, A3 for PTZ at 70 mg/kg and dapaglifozin at 75 mg/kg, A4 for PTZ at 70 mg/kg and dapaglifozin at 150 mg/kg. Superscript (*) denotes a statistically significant difference between the current arm and A2, with p < 0.001. Superscript (**) denotes a statistically significant difference between the current arm and A2, with p < 0.05

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