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Table 1 Additional parameters and results from the EEG experiments

From: Highly selective SGLT2 inhibitor dapagliflozin reduces seizure activity in pentylenetetrazol-induced murine model of epilepsy

Arm Seizure onset (seconds) Duration of single seizures (seconds) Duration of high frequency or high amplitude spiking (seconds) Total seizure duration (seconds)
A1 0 ± 0.0 0 ± 0.0 0 ± 0.0 0 ± 0.0
A2 45.08 ± 9.3 10.2 ± 3.10 5.3 ± 0.93 2564.2 ± 105.6
A3 110.3 ± 16.8** 6.06 ± 1.08* 3.2 ± 0.85* 685.2 ± 60.8**
A4 185.7 ± 12.1** 2.1 ± 0.93* 0.8 ± 0.12* 451.8 ± 35.9**
  1. The treatment arms are as follows: A1 for saline (control arm), A2 for PTZ at 70 mg/kg and saline, A3 for PTZ at 70 mg/kg and dapaglifozin at 75 mg/kg, A4 for PTZ at 70 mg/kg and dapaglifozin at 150 mg/kg. Superscript (*) denotes a statistically significant difference between the current arm and A2, with p < 0.001. Superscript (**) denotes a statistically significant difference between the current arm and A2, with p < 0.05