From: Environmental exposures and the risk of multiple sclerosis in Saudi Arabia
Environmental exposures | Exposed cases/Exposed controls (n = 307/307) | Crude OR | 95% CI | P value |
---|---|---|---|---|
First child in family, yes/no | 76/264 | 2.02 | 1.34–3.06 | 0.001 |
Family history of MS, yes/no | 57/294 | 5.16 | 2.76–9.64 | < 0.001 |
Sun exposure during primary school, high/low | 139/122 | 0.55 | 0.40–0.75 | < 0.001 |
Sun exposure during intermediate school, high/low | 94/169 | 0.54 | 0.39–0.75 | < 0.001 |
Sun exposure during secondary school, high/low | 65/192 | 0.45 | 0.31–0.64 | < 0.001 |
Sun exposure during university school, high/lowa | 54/184 | 0.33 | 0.23 – 0.49 | < 0.001 |
Breastfeeding, yes/nob | 203/37 | |||
≥ 5 Servings of fruits / week, yes/no | 77/145 | 0.30 | 0.21–0.42 | < 0.001 |
≥ 5 Servings of vegetables / week, yes/no | 145/120 | 0.57 | 0.42–0.79 | 0.001 |
≥ 5 dates times / week, yes/no | 156/146 | 0.94 | 0.68–1.29 | 0.69 |
≥ 5 red meat times / week, yes/no | 38/268 | 0.97 | 0.60–1.57 | 0.90 |
≥ 5 milk times / week, yes/no | 84/239 | 1.32 | 0.92–1.91 | 0.14 |
≥ 5 Fast food times/week, yes/no | 46/291 | 3.21 | 1.77–5.80 | < 0.001 |
≥ 5 Dairy products times / week, yes/no | 162/172 | 1.42 | 1.04–1.96 | 0.03 |
Daily coffee intake, yes/no | 112/147 | 0.53 | 0.38–0.73 | < 0.001 |
Illness or surgical interventions: | ||||
History of measles infection, yes/no | 63/283 | 3.05 | 1.85–5.02 | < 0.001 |
History of chicken pox infection, yes/no | 167/132 | 0.90 | 0.65–1.24 | 0.57 |
Appendectomy, yes/no | 29/268 | 0.72 | 0.43–1.19 | 0.25 |
Tonsillectomy, yes/no | 52/264 | 1.25 | 0.81–1.94 | 0.37 |
Medical history: | ||||
Type I diabetes mellitus, yes/no | 15/285 | 0.67 | 0.34–1.31 | 0.235 |
Migraine, yes/no | 35/269 | 0.91 | 0.56–1.49 | 0.71 |
Systematic lupus erythematosus, yes/no | 1/302 | 0.19 | 0.02–1.69 | 0.22 |
Rheumatoid arthritis, yes/no | 17/289 | 0.94 | 0.48–1.86 | 0.86 |
Thyroid disorder, yes/no | 19/274 | 0.55 | 0.30–0.99 | 0.04 |
Crohn’s disease, yes/no | 1/306 | 1 | 0.06–16.06 | 1 |
Ulcerative colitis, yes/no | 18/294 | 1.41 | 0.68–2.93 | 0.36 |
Psoriasis, yes/no | 7/303 | 1.77 | 0.51–6.10 | 0.361 |
Family history of medical conditions: | ||||
Type I diabetes mellitus, yes/no | 154/154 | 1.01 | 0.74–1.39 | 0.94 |
Migraine, yes/no | 53/249 | 0.90 | 0.59–1.35 | 0.60 |
Systematic lupus erythematosus, yes/no | 10/291 | 0.61 | 0.27–1.37 | 0.23 |
Rheumatoid arthritis, yes/no | 69/239 | 1.02 | 0.70–1.49 | 0.92 |
≥ 13-year age of menarche, yes/no | 98/138 | 1.11 | 0.77–1.61 | 0.57 |
Tobacco use: | ||||
Current tobacco use, cases/controls | 58/52 | 1.16 | 0.77–1.76 | 0.47 |
Ex-smoker, cases/controls | 19/15 | 1.32 | 0.84–1.56 | 0.43 |
Never smoker, cases/controls | 230/240 | Ref. | ||
Passive smoking in childhood, yes/no | 113/194 | 1 | 0.72–1.39 | 1 |
BMI: | ||||
≥ 30, cases/controls | 76/74 | 0.92 | 0.62–1.37 | 0.67 |
25–29.99, cases/controls | 90/107 | 0.75 | 0.52–1.09 | 0.13 |
≤ 24.99, cases/controls | 141/126 | Ref. | ||
Parental consanguinity (first cousin), yes/no | 63/222 | 0.67 | 0.46–0.98 | 0.03 |