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Table 2 Bivariate analysis of variables associated with risk of Multiple Sclerosis

From: Environmental exposures and the risk of multiple sclerosis in Saudi Arabia

Environmental exposures

Exposed cases/Exposed controls (n = 307/307)

Crude OR

95% CI

P value

 First child in family, yes/no

76/264

2.02

1.34–3.06

0.001

 Family history of MS, yes/no

57/294

5.16

2.76–9.64

< 0.001

 Sun exposure during primary school, high/low

139/122

0.55

0.40–0.75

< 0.001

 Sun exposure during intermediate school, high/low

94/169

0.54

0.39–0.75

< 0.001

 Sun exposure during secondary school, high/low

65/192

0.45

0.31–0.64

< 0.001

 Sun exposure during university school, high/lowa

54/184

0.33

0.23 – 0.49

< 0.001

 Breastfeeding, yes/nob

203/37

   

 ≥ 5 Servings of fruits / week, yes/no

77/145

0.30

0.21–0.42

< 0.001

 ≥ 5 Servings of vegetables / week, yes/no

145/120

0.57

0.42–0.79

0.001

 ≥ 5 dates times / week, yes/no

156/146

0.94

0.68–1.29

0.69

 ≥ 5 red meat times / week, yes/no

38/268

0.97

0.60–1.57

0.90

 ≥ 5 milk times / week, yes/no

84/239

1.32

0.92–1.91

0.14

 ≥ 5 Fast food times/week, yes/no

46/291

3.21

1.77–5.80

< 0.001

 ≥ 5 Dairy products times / week, yes/no

162/172

1.42

1.04–1.96

0.03

 Daily coffee intake, yes/no

112/147

0.53

0.38–0.73

< 0.001

Illness or surgical interventions:

 History of measles infection, yes/no

63/283

3.05

1.85–5.02

< 0.001

 History of chicken pox infection, yes/no

167/132

0.90

0.65–1.24

0.57

 Appendectomy, yes/no

29/268

0.72

0.43–1.19

0.25

 Tonsillectomy, yes/no

52/264

1.25

0.81–1.94

0.37

Medical history:

 Type I diabetes mellitus, yes/no

15/285

0.67

0.34–1.31

0.235

 Migraine, yes/no

35/269

0.91

0.56–1.49

0.71

 Systematic lupus erythematosus, yes/no

1/302

0.19

0.02–1.69

0.22

 Rheumatoid arthritis, yes/no

17/289

0.94

0.48–1.86

0.86

 Thyroid disorder, yes/no

19/274

0.55

0.30–0.99

0.04

 Crohn’s disease, yes/no

1/306

1

0.06–16.06

1

 Ulcerative colitis, yes/no

18/294

1.41

0.68–2.93

0.36

 Psoriasis, yes/no

7/303

1.77

0.51–6.10

0.361

Family history of medical conditions:

 Type I diabetes mellitus, yes/no

154/154

1.01

0.74–1.39

0.94

 Migraine, yes/no

53/249

0.90

0.59–1.35

0.60

 Systematic lupus erythematosus, yes/no

10/291

0.61

0.27–1.37

0.23

 Rheumatoid arthritis, yes/no

69/239

1.02

0.70–1.49

0.92

 ≥ 13-year age of menarche, yes/no

98/138

1.11

0.77–1.61

0.57

Tobacco use:

 Current tobacco use, cases/controls

58/52

1.16

0.77–1.76

0.47

 Ex-smoker, cases/controls

19/15

1.32

0.84–1.56

0.43

 Never smoker, cases/controls

230/240

Ref.

  

 Passive smoking in childhood, yes/no

113/194

1

0.72–1.39

1

BMI:

 ≥ 30, cases/controls

76/74

0.92

0.62–1.37

0.67

 25–29.99, cases/controls

90/107

0.75

0.52–1.09

0.13

 ≤ 24.99, cases/controls

141/126

Ref.

  

 Parental consanguinity (first cousin), yes/no

63/222

0.67

0.46–0.98

0.03

  1. aNot applicable (5 MS cases and 3 controls)
  2. bNot know (58 cases and 52 controls)