Shanghai cognitive intervention of mild cognitive impairment for delaying progress with longitudinal evaluation-a prospective, randomized controlled study (SIMPLE): rationale, design, and methodology

Table 1 Forbidden and restricted medication in the trial

Forbidden medication	Cholinesterase inhibitors
	N-methyl-D-aspartate (NMDA) antagonists
	Synthetic adrenal corticosteroids
	Central nervous system stimulants
	Chinese and western cognitive improvement medication
Restricted medication^a	Antipsychotics
	Antidepressants
	Sedative-hypnotics^b

Restricted medication^a: The dose of these medications should not be increased during the trial. Patients with these medications for a long time should keep the dose stable
Sedative-hypnotics^b: If necessary, temporary use of zopiclone, alprazolam or estazolam is allowed. Last dose before psychological assessment should not be given later than 22:00 last night

ISSN: 1471-2377