| Screening | Run-in | Baseline | 1st Visits | 2nd Visit | 3rd Visit | 4th Visit | 5th Visit | Endpointa |
---|---|---|---|---|---|---|---|---|---|
Time Points | −3 weeks | −2 weeks | 0 | 6 months | 2 months | 18 months | 24 months | 30 months | 36 months |
Written informed consent |  | × |  |  |  |  |  |  |  |
Inclusion/exclusion criteria | × | × | × |  |  |  |  |  |  |
Blood test |  | × |  |  |  |  |  |  |  |
Electrocardiogram |  | × |  |  |  |  |  |  |  |
Cranial MRI examination |  | × |  |  | × |  |  |  | × |
MMSE | × |  | × | × | × | × | × | × | × |
ADAS-Cog |  |  | × | × | × | × | × | × | × |
ADCS-ADL |  |  | × | × | × | × | × | × | × |
HAMD/GDS | × |  | × |  | × |  | × |  | × |
AVLT |  |  | × |  | × |  | × |  | × |
TMT |  |  | × |  | × |  | × |  | × |
CFT |  |  | × |  | × |  | × |  | × |
Stroop Test |  |  | × |  | × |  | × |  | × |
Boston Naming Test |  |  | × |  | × |  | × |  | × |