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Table 2 Outline and timelines of the trial

From: Shanghai cognitive intervention of mild cognitive impairment for delaying progress with longitudinal evaluation-a prospective, randomized controlled study (SIMPLE): rationale, design, and methodology

 

Screening

Run-in

Baseline

1st Visits

2nd Visit

3rd Visit

4th Visit

5th Visit

Endpointa

Time Points

−3 weeks

−2 weeks

0

6 months

2 months

18 months

24 months

30 months

36 months

Written informed consent

 

×

       

Inclusion/exclusion criteria

×

×

×

      

Blood test

 

×

       

Electrocardiogram

 

×

       

Cranial MRI examination

 

×

  

×

   

×

MMSE

×

 

×

×

×

×

×

×

×

ADAS-Cog

  

×

×

×

×

×

×

×

ADCS-ADL

  

×

×

×

×

×

×

×

HAMD/GDS

×

 

×

 

×

 

×

 

×

AVLT

  

×

 

×

 

×

 

×

TMT

  

×

 

×

 

×

 

×

CFT

  

×

 

×

 

×

 

×

Stroop Test

  

×

 

×

 

×

 

×

Boston Naming Test

  

×

 

×

 

×

 

×

  1. aEndpoint is either the ending of 36-month follow-up or the diagnosis of AD during follow-up