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Table 2 S-IGF-I for patients included by etiology, stroke subtype and severity, respectively

From: Altered levels of circulating insulin-like growth factor I (IGF-I) following ischemic stroke are associated with outcome - a prospective observational study

  Mean   Mean   Mean
ΔIGF-I P Acute IGF-I P 3-month IGF-I P Age P
(SD)   (SD)   (SD)    
Stroke severity (NIHSS†)   Dunnett, q1 vs. q2-q5       
 q1 (mild) 21.6 (42.0) N/A 162.4 (59.5) N/A 140.8 (50.0) N/A 53.1 (12.5) N/A
 N 82   82   82   82  
 q2 (minor) 29.0 (51.0) ns 181.9 (67.0) ns 152.9 (53.1) ns 55.7 (9.9) ns
 N 66   66   66   66  
 q3 (moderate) 20.6 (49.5) ns 168.1 (63.5) ns 147.6 (56.0) ns 54.4 (11.1) ns
 N 66   66   66   66  
 q4 (major) 28.3 (72.7) ns 181.6 (61.8) ns 153.4 (53.6) ns 58.4 (9.5) 0.01
 N 73   73   73   73  
 q5 (severe) 0.58 (58.5) 0.04 171.7 (62.5) ns 171.2 (63.2) 0.003 54.0 (10.7) ns
 N 67   67   67   67  
 Missing (n) 0   0   0   0  
Subtype (OCSP)   Tukey’s crosswise       
 Lacunar cerebral infarction (LACI) 21.1 (37.0) 0.09-TACI 163.9 (57.4) ns 142.8 (48.5) **TACI 56.6 (9.6) 0.05-POCI
 N 113   113   113   113  
 Partial anterior cerebral infarction (PACI) 18.1 (47.3) ns 172.8 (67.9) ns 154.7 (59.5) ns 55.0 (11.3) ns
 N 104   104   104   104  
 Posterior cerebral infarction (POCI) 30.7 (59.4) **TACI 181.6 (65.4) ns 150.9 (57.1) ns 52.7 (12.2) 0.11-TACI
 N 94   94   94   94 0.05-LACI
 Total anterior cerebral infarction (TACI) −1.5 (68.1) **POCI 171.7 (58.4) ns 173.3 (57.1) **LACI 52.7 (9.3) 0.11-POCI
 N 37 0.09-LACI 37   37   37  
 Missing (N) 6   6   6   6  
Etiology (TOAST)   Tukey’s crosswise       
 Large vessel diseaase (LVD) 20.4 (53.7) ns 181.1 (57.0) *D 160.8 (57.9) ns 59.0 (7.8) ***D, **Cr
 N 51   51 0.08-CE 51   51  
 Small vessel diseaase (SVD) 19.1 (39.6) ns 161.4 (60.6) ***D 142.3 (53.4) **D 58.4 (7.2) ***D, **Cr
 N 69   69   69   69  
 Cardioembolic (CE) 6.1 (46.2) ns 151.2 (53.3) ***D, 0.08-LVD 145.1 (51.1) *D 55.5)11.6) *D
 N 52   52 0.15-Cr 52   52  
 Cryptogenic (Cr) 20.1 (43.3) ns 174.1 (60.7) ***D 154.0 (53.9) 0.09 vs. D 53.1 (11.9) **LVD/SVD
 N 112   112 0.15-CE 112   112  
 Arterial dissection (D) 40.1 (95.7) *CE 223.7 (63.0) ***SVD/CE/Cr 183.6 (66.7) **-SVD 48.1 (9.4) ***LVD/SVD
 N 27   27 *LVD 27 *CE, 0.09-Cr 27 **Cr, 0.14-D
 Other/undeterrmined 26.2 (45.7) N/A 172.2 (71.9) N/A 146.0 (53.7) N/A 54.2 (13.5) N/A
 n 43   43   43   43  
 Missing (N) 0   0   0   0  
  1. P-values less than 0.3 are specified although they are considered being not signicant (ns). * < 0.05, ** < 0.01. *** < 0.001 for Dunnett’s or Tukey’s post-hoc tests as indicated. As we have a slightly different number of included patients, and using NIHSS instead of SSS as it was presented in 2011, we present s-IGF-I (acute, 3-month) for comparison with the present inclusion (n = 354). TOAST = Trial of Org 10,172 in Acute Stroke Treatment [1], OCSP = Oxfordshire Community Stroke Project [4]. All variation shown is given in standard deviations (SD). N/A designates not applicable. †Scoring of neurological function is taken from the original SSS scores and converted to NIHSS (methods)