Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS)

Table 1 Median and range for average number of nocturia episodes, voided output, and NPI by treatment with treatment p-value and standardized effect size, d

Measure	Treatment
	Baseline		A: Placebo		B: Melatonin		p	d
	Median	Range	Median	Range	Median	Range	p	d
Average Nocturia Episodes	1.70	1–3	1.50	0–3	1.30	0–3.3	0.618	0.136
Average nocturnal urine output (mls)	741	310–1416	651	300–1933	667	200–1100	0.939	0.020
24-h voided volume (mls)	2125	1200–4000	2213	1250–3900	2000	881–3600	0.254	0.314
Nocturnal Polyuria Index NPI	0.32	0.15–0.71	0.33	0.17–0.56	0.32	0.15–0.60	0.849	0.052

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