Results of a randomized, double blind, placebo controlled, crossover trial of melatonin for treatment of Nocturia in adults with multiple sclerosis (MeNiMS)

Table 4 Median and range for MSQoL by treatment, with p-value and standardized effect size, d

Measure	Treatment
	A: Placebo		B: Melatonin		p	d
	Median	Range	Median	Range	p	d
Mental Overall Score	68.0	16–92	75.0	28–92	0.110	0.446
Physical Overall Score	44.0	17–89	48.5	21–90	0.023	0.651
Energy Score	30.0	0–76	36.0	0–84	0.212	0.347
Emotional Wellbeing	68.0	32–100	72.0	32–100	0.961	0.013
Physical Health	45.0	5–100	40.0	5–100	0.701	0.105
Role limitations due to physical problems	12.5	0–100	25.0	0–100	0.015	0.701
Role limitations due to emotional problems	100	0–100	100	0–100	0.580	0.151
Health Perceptions	42.5	5–85	45.0	0–80	0.396	0.233
Social Function	67.0	25–100	67.0	0–100	0.603	0.142
Cognitive Function	67.0	0–100	73.0	0–100	0.884	0.040
Health Distress	60.0	15–90	60.0	0–100	0.862	0.036
Change in Health	25.0	0–50	50.0	25–100	0.647	0.125
Quality of Life	55.0	27–95	63.0	0–90	0.130	0.421
Pain Score	78.0	0–100	70.0	0–100	0.029	0.622

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