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Table 2 Clinical findings of patients with svPPA who underwent [18F]THK-5351 PET imaging

From: [18F]THK-5351 PET imaging in early-stage semantic variant primary progressive aphasia: a report of two cases and a literature review

Reference

Sex/age

(years)

Duration

(years)

MMSE

(/30)

Clinical presentation

Atrophy- predominant

MRI findings

THK-5351 retention

Takaya M et al., 2017 [7]

F/69

5

12

Comprehension difficulty, surface dyslexia

L > R

Bilateral anterior temporal lobe atrophy

Bilateral anterior temporal regions

Lee H et al., 2017 [8]

F/79

4

8

(average of 5 cases)

Comprehension difficulty, compulsive behavior

L > R

Bilateral anterior temporal lobe atrophy

Bilateral anterolateral temporal regions

F/76

3

8

(average of 5 cases)

Anomia, comprehension difficulty, inappropriate social behavior

R > L

Bilateral anterior temporal lobe atrophy

Bilateral anterolateral temporal regions

M/50

10

8

(average of 5 cases)

Anomia, comprehension difficulty, prosopagnosia, behavioral changes

L > R

Bilateral anterior temporal lobe atrophy

Bilateral anterolateral temporal regions

F/60

1

8

(average of 5 cases)

Comprehension difficulty, prosopagnosia, behavioral changes

L > R

Bilateral anterior temporal lobe atrophy

Bilateral anterolateral temporal regions

M/66

2

8

(average of 5 cases)

Anomia, comprehension difficulty

L > R

Bilateral anterior temporal lobe atrophy

Bilateral anterolateral temporal regions

Jang YK et al., 2017 [9]

M/68

NA

20

Decreased understanding ability, confusion about names of objects

R > L

Bilateral anterior temporal lobe atrophy

Bilateral anterior and inferior temporal regions

  1. F female, L left, M male, MRI magnetic resonance imaging, NA not available, R right, svPPA semantic variant primary progressive aphasia, THK-5351: [18F]THK-5351