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Table 2 Post-translational modifications (PTMs) of 18 isoforms of cerebrospinal fluid alpha-1-antitrypsin

From: Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

SPOT NUMBER Mw (kDa) pI Unique peptides Peptides position START-END PTM
1605 153.0 5.50 18 35–418 N-glycosylation
1606 153.0 5.52 18 35–418 N-glycosylation
2601 153.0 5.54 18 35–418 N-glycosylation
1310 70.9 5.25 14 35–418
1308 69.5 5.35 20 35–418
2311 69.5 5.39 25 35–418
2310 68.2 5.44 25 35–418
2308 68.2 5.50 31 35–418
216 36.7 4.78 6 180–411 N-terminal truncation
215 35.4 4.80 16 126–418 N-terminal truncation
214 33.4 4.90 6 35–241 C-terminal truncation
111 38.9 5.10 10 126–418 N-terminal truncation
110 37.4 5.15 16 154–418 N-terminal truncation
5106 19.4 6.50 7 299–418 N-terminal truncation
1505 57.6 5.3 12 35–418 N-glycosylation
2504 60.9 5.5 12 35–418 N-glycosylation
2508 68.3 5.5 12 35–418 N-glycosylation
2512 68.2 5.4 12 35–418 N-glycosylation