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Table 3 Proteins associated with Visual Analogue Pain Intensity last week (VASPI) in patients with peripheral neuropathic pain

From: Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

SPOT NB

VASPI-VIP

Protein name

Bivariate correlation with VASPI

Spearman’s rho

p-value

2515

2.41

Alpha-1-antitrypsin

0.77

0.005*

3308

2.38

Pigment epithelium-derived factor

0.75

0.008*

4204

2.31

Fibrinogen gamma chain

0.72

0.012*

3211

2.14

Pigment epithelium-derived factor

0.58

0.064

7001

2.11

Prostaglandin-H2 D-isomerase

0.63

0.040*

6105

2.01

Kallikrein-6

0.62

0.041*

6104

2.00

Prostaglandin-H2 D-isomerase

−0.54

0.084

1111

1.97

Apolipoprotein E

0.66

0.028*

2405

1.89

Antithrombin

0.65

0.031*

2514

1.87

Beta-Ala-His dipeptidase

0.46

0.163

6613

1.84

Serotransferrin

0.70

0.016*

110

1.83

Alpha-1-antitrypsin

−0.68

0.022*

6206

1.79

Serotransferrin

0.52

0.104

1506

1.78

Beta-Ala-His dipeptidase

0.14

0.678

8004

1.77

Prostaglandin-H2 D-isomerase

−0.26

0.440

7202

1.76

Procollagen C-endopeptidase enhancer 1

0.38

0.244

111

1.75

Alpha-1-antitrypsin

−0.78

0.005*

3409

1.73

Angiotensinogen

0.81

0.003*

6205

1.72

Serotransferrin

−0.45

0.163

8108

1.67

Prostaglandin-H2 D-isomerase

−0.40

0.226

4611

1.66

Hemopexin

0.48

0.140

1205

1.64

Complement factor B

−0.62

0.041*

2205

1.64

Haptoglobin

0.30

0.375

2522

1.63

prothrombin

0.40

0.226

7713

1.62

plasminogen

−0.73

0.103

3302

1.61

Antithrombin

0.55

0.081

2504

1.61

Alpha-1-antitrypsin

0.37

0.257

8414

1.60

IgG heavy chain

−0.44

0.177

6304

1.58

Beta-2-glycoprotein 1

−0.21

0.535

8204

1.57

Prostaglandin-H2 D-isomerase

0.24

0.473

9507

1.56

Complement C4-A

−0.28

0.399

5620

1.55

Serum Albumin

0.42

0.204

3204

1.53

Pigment epithelium-derived factor

0.56

0.075

8413

1.52

IgG heavy chain

−0.23

0.491

7407

1.50

IgG heavy chain

−0.26

0.440

  1. Note: Proteins are listed in decreasing order of importance according to Variable Influence on Projection (VIP) of the OPLS model. Only protein isoforms with VIP ≥ 1.5 are reported (see Methods section). Spot NB refers to the marked protein spot in Additional file 1: Figure S1
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BMC Neurology

ISSN: 1471-2377

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