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Table 3 Proteins associated with Visual Analogue Pain Intensity last week (VASPI) in patients with peripheral neuropathic pain

From: Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

SPOT NB VASPI-VIP Protein name Bivariate correlation with VASPI
Spearman’s rho p-value
2515 2.41 Alpha-1-antitrypsin 0.77 0.005*
3308 2.38 Pigment epithelium-derived factor 0.75 0.008*
4204 2.31 Fibrinogen gamma chain 0.72 0.012*
3211 2.14 Pigment epithelium-derived factor 0.58 0.064
7001 2.11 Prostaglandin-H2 D-isomerase 0.63 0.040*
6105 2.01 Kallikrein-6 0.62 0.041*
6104 2.00 Prostaglandin-H2 D-isomerase −0.54 0.084
1111 1.97 Apolipoprotein E 0.66 0.028*
2405 1.89 Antithrombin 0.65 0.031*
2514 1.87 Beta-Ala-His dipeptidase 0.46 0.163
6613 1.84 Serotransferrin 0.70 0.016*
110 1.83 Alpha-1-antitrypsin −0.68 0.022*
6206 1.79 Serotransferrin 0.52 0.104
1506 1.78 Beta-Ala-His dipeptidase 0.14 0.678
8004 1.77 Prostaglandin-H2 D-isomerase −0.26 0.440
7202 1.76 Procollagen C-endopeptidase enhancer 1 0.38 0.244
111 1.75 Alpha-1-antitrypsin −0.78 0.005*
3409 1.73 Angiotensinogen 0.81 0.003*
6205 1.72 Serotransferrin −0.45 0.163
8108 1.67 Prostaglandin-H2 D-isomerase −0.40 0.226
4611 1.66 Hemopexin 0.48 0.140
1205 1.64 Complement factor B −0.62 0.041*
2205 1.64 Haptoglobin 0.30 0.375
2522 1.63 prothrombin 0.40 0.226
7713 1.62 plasminogen −0.73 0.103
3302 1.61 Antithrombin 0.55 0.081
2504 1.61 Alpha-1-antitrypsin 0.37 0.257
8414 1.60 IgG heavy chain −0.44 0.177
6304 1.58 Beta-2-glycoprotein 1 −0.21 0.535
8204 1.57 Prostaglandin-H2 D-isomerase 0.24 0.473
9507 1.56 Complement C4-A −0.28 0.399
5620 1.55 Serum Albumin 0.42 0.204
3204 1.53 Pigment epithelium-derived factor 0.56 0.075
8413 1.52 IgG heavy chain −0.23 0.491
7407 1.50 IgG heavy chain −0.26 0.440
  1. Note: Proteins are listed in decreasing order of importance according to Variable Influence on Projection (VIP) of the OPLS model. Only protein isoforms with VIP ≥ 1.5 are reported (see Methods section). Spot NB refers to the marked protein spot in Additional file 1: Figure S1