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Table 4 Proteins associated with pain duration in patients with peripheral neuropathic pain

From: Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

SPOT NB Pain duration-VIP Protein name Bivariate correlation with pain duration
Spearman’s rho p-value
2312 2.31 Zinc-Alpha-2-glycoprotein 0.50 0.120
7712 2.27 Plasminogen 0.82 0.023*
1205 2.26 Complement factor B 0.78 0.005*
7711 2.23 Plasminogen 0.61 0.148
3502 2.16 Hemopexin 0.55 0.082
3309 2.15 Haptoglobin 0.29 0.392
4309 2.14 Haptoglobin 0.71 0.071
2106 2.09 Apolipoprotein E 0.55 0.079
206 2.07 Haptoglobin 0.77 0.072
2601 2.05 Alpha-1-antitrypsin 0.89 0.019*
3106 2.03 Clusterin −0.67 0.024*
3409 1.95 Angiotensinogen −0.39 0.233
409 1.93 Alpha-2-HS-glycoprotein 0.46 0.159
1203 1.86 Haptoglobin 0.52 0.105
7713 1.86 Plasminogen 0.77 0.072
6001 1.82 Alpha-1-antitrypsin −0.54 0.091
2311 1.82 Alpha-1-antitrypsin 0.38 0.245
6611 1.75 Serotransferrin −0.57 0.067
6614 1.73 Serotransferrin −0.58 0.062
6610 1.72 Serotransferrin −0.67 0.023*
3111 1.71 Prostaglandin-H2 D-isomerase −0.54 0.085
412 1.69 Alpha-2-HS-glycoprotein 0.44 0.179
6609 1.67 Serotransferrin −0.72 0.013*
1211 1.67 Haptoglobin 0.30 0.377
3210 1.66 Haptoglobin 0.52 0.098
3010 1.66 Tetranectin −0.21 0.527
2310 1.63 Alpha-1-antitrypsin 0.25 0.466
7403 1.61 Complement C3 0.59 0.055
4105 1.61 Prostaglandin-H2 D-isomerase −0.51 0.113
5306 1.59 Pigment epithelium-derived factor −0.60 0.050
2108 1.57 Apolipoprotein E −0.56 0.073
208 1.56 Haptoglobin 0.35 0.290
8001 1.55 Phosphatidylethanolamine binding protein −0.46 0.154
1111 1.53 Apolipoprotein E −0.55 0.082
  1. Note: Proteins are listed in decreasing order of importance according to Variable Influence on Projection (VIP) of the OPLS model. Only protein isoforms with VIP ≥ 1.5 are reported (see Methods section). Spot NB refers to the marked protein spot in Additional file 1: Figure S1