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Table 4 Proteins associated with pain duration in patients with peripheral neuropathic pain

From: Do fragments and glycosylated isoforms of alpha-1-antitrypsin in CSF mirror spinal pathophysiological mechanisms in chronic peripheral neuropathic pain? An exploratory, discovery phase study

SPOT NB

Pain duration-VIP

Protein name

Bivariate correlation with pain duration

Spearman’s rho

p-value

2312

2.31

Zinc-Alpha-2-glycoprotein

0.50

0.120

7712

2.27

Plasminogen

0.82

0.023*

1205

2.26

Complement factor B

0.78

0.005*

7711

2.23

Plasminogen

0.61

0.148

3502

2.16

Hemopexin

0.55

0.082

3309

2.15

Haptoglobin

0.29

0.392

4309

2.14

Haptoglobin

0.71

0.071

2106

2.09

Apolipoprotein E

0.55

0.079

206

2.07

Haptoglobin

0.77

0.072

2601

2.05

Alpha-1-antitrypsin

0.89

0.019*

3106

2.03

Clusterin

−0.67

0.024*

3409

1.95

Angiotensinogen

−0.39

0.233

409

1.93

Alpha-2-HS-glycoprotein

0.46

0.159

1203

1.86

Haptoglobin

0.52

0.105

7713

1.86

Plasminogen

0.77

0.072

6001

1.82

Alpha-1-antitrypsin

−0.54

0.091

2311

1.82

Alpha-1-antitrypsin

0.38

0.245

6611

1.75

Serotransferrin

−0.57

0.067

6614

1.73

Serotransferrin

−0.58

0.062

6610

1.72

Serotransferrin

−0.67

0.023*

3111

1.71

Prostaglandin-H2 D-isomerase

−0.54

0.085

412

1.69

Alpha-2-HS-glycoprotein

0.44

0.179

6609

1.67

Serotransferrin

−0.72

0.013*

1211

1.67

Haptoglobin

0.30

0.377

3210

1.66

Haptoglobin

0.52

0.098

3010

1.66

Tetranectin

−0.21

0.527

2310

1.63

Alpha-1-antitrypsin

0.25

0.466

7403

1.61

Complement C3

0.59

0.055

4105

1.61

Prostaglandin-H2 D-isomerase

−0.51

0.113

5306

1.59

Pigment epithelium-derived factor

−0.60

0.050

2108

1.57

Apolipoprotein E

−0.56

0.073

208

1.56

Haptoglobin

0.35

0.290

8001

1.55

Phosphatidylethanolamine binding protein

−0.46

0.154

1111

1.53

Apolipoprotein E

−0.55

0.082

  1. Note: Proteins are listed in decreasing order of importance according to Variable Influence on Projection (VIP) of the OPLS model. Only protein isoforms with VIP ≥ 1.5 are reported (see Methods section). Spot NB refers to the marked protein spot in Additional file 1: Figure S1