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Fig. 2 | BMC Neurology

Fig. 2

From: Peripheral neuropathy in a case with CADASIL: a case report

Fig. 2

Pathological investigations on right sural nerve biopsy. The density of myelinated fibers slightly reduced (7303/mm2; normal range 7500–11,000 fibers/mm2), mostly damaged those of large diameter. a: Toluidine blue-stained semithin epon section. Some axon with thickest myelin and myelin ovoids appeared, suggesting axonal degeneration. Demyelinated fiber was absent. There were no inflammatory cell and subperineurial edema. b: Electron microscope study. Granular osmiophilic material (arrows) was viewed in the electron microscope, deposited between the smooth muscle cells surrounding a small artery in epineurial connective tissue

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