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Table 1 Patients characteristics at low and high positive end-expiratory pressure

From: Intracranial pressure responsiveness to positive end-expiratory pressure is influenced by chest wall elastance: a physiological study in patients with aneurysmal subarachnoid hemorrhage

  Low PEEP (5 cmH2O) High PEEP (15 cmH2O) p
ICP and hemodynamic parameters
 ICP (mmHg) 4.0 (2.0–10.0) 7.0 (5.8–11.0) <  0.001
 MAP (mmHg) 81.0 (75.6–92.1) 76.2 (67.4–90.0) 0.002
 CPP (mmHg) 74.7 (69.6–86.8) 68.7 (60.6–82.7) <  0.001
 CVP (mmHg) 8.0 (5.0–10.0) 12.0 (10.0–14.0) <  0.001
Respiratory mechanics parameters
 VT (mL/kg) 7.7 (7.1–8.3) 7.7 (7.1–8.2) 0.304
 ∆PAW (cmH2O) 6.8 (6.5–9.5) 9.5 (7.8–10.9) <  0.001
 ∆PCW (cmH2O) 2.7 (1.4–3.1) 2.7 (2.7–4.1) 0.003
 ∆PL (cmH2O) 4.8 (4.1–5.8) 6.8 (4.1–8.2) 0.003
 ERS (cmH2O/L) 15.3 (12.5–18.6) 20.1 (16.2–23.9) <  0.001
 ECW (cmH2O/L) 5.5 (2.9–6.9) 6.2 (5.4–10.2) 0.001
 EL (cmH2O/L) 9.4 (7.9–12.1) 12.9 (8.5–15.6) 0.004
 ECW/ERS ratio 0.33 (0.25–0.43) 0.40 (0.29–0.47) 0.247
 Resistance (cmH2O/L/sec) 13.0 (9.9–14.2) 12.6 (10.1–15.0) 0.894
Blood gas analysis parameters
 pH 7.40 (7.36–7.44) 7.42 (7.38–7.45) 0.951
 PaO2 (mmHg) 105.5 (78.0–153.5) 115.5 (78.4–163.5) 0.058
 PaO2/FiO2 264 (180–384) 289 (185–388) 0.061
 PaCO2 (mmHg) 35.3 (32.6–36.7) 35.3 (33.6–38.2) 0.052
 PETCO2 (mmHg) 29.5 (27.8–31.2) 29.0 (25.8–30.3) 0.003
 VDalv/VT (%) 13.2 (8.5–19.9) 18.8 (11.9–27.7) <  0.001
  1. Data are shown as median (interquartile range)
  2. ICP intracranial pressure; MAP mean arterial pressure; CPP cerebral perfusion pressure; CVP central venous pressure; VT tidal volume; ∆PAW airway driving pressure; ∆PCW chest wall driving pressure; ∆PL: transpulmonary driving pressure; ERS respiratory system elastance; ECW chest wall elastance; EL lung elastance; PETCO2 end-tidal carbon dioxide partial pressure; VDalv/VT: ratio of the alveolar dead space to the tidal volume