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Fig. 3 | BMC Neurology

Fig. 3

From: Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsing–remitting multiple sclerosis at year 1

Fig. 3

Proportions free from relapses, disability progression, and active T2 lesions up to 1 year. Based on a logistic regression adjusting for age (< 40 vs. ≥40 years), sex, baseline EDSS score (≤3.5 vs. > 3.5), number of relapses prior to the study within 24 months, and time since MS onset; p values indicate effect of IFN β-1a SC tiw compared with placebo. Values within parentheses are 95% CI values. Active T2 lesions obtained at 6-month and 1-year scans were included. aEndpoint is missing if the patient withdrew before the first year and did not have any relapses. bEndpoint is missing if the patient withdrew before the first year and did not have 3-month confirmed EDSS progression before withdrawal; EDSS progression was defined as 1-point increase in EDSS score if the baseline EDSS score was < 6.0 or 0.5-point increase if the baseline EDSS score was ≥6.0 (EDSS scores could be > 5 if scores increased between screening and baseline). cEndpoint is missing if the patient withdrew before the first year and did not have any active T2 lesions. CI: confidence interval; EDSS: Expanded Disability Status Scale; IFN β-1a: interferon beta-1a; OR: odds ratio; SC: subcutaneously; tiw: three times weekly

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