Fig. 3

Proportions free from relapses, disability progression, and active T2 lesions up to 1 year. Based on a logistic regression adjusting for age (< 40 vs. ≥40 years), sex, baseline EDSS score (≤3.5 vs. > 3.5), number of relapses prior to the study within 24 months, and time since MS onset; p values indicate effect of IFN β-1a SC tiw compared with placebo. Values within parentheses are 95% CI values. Active T2 lesions obtained at 6-month and 1-year scans were included. ^aEndpoint is missing if the patient withdrew before the first year and did not have any relapses. ^bEndpoint is missing if the patient withdrew before the first year and did not have 3-month confirmed EDSS progression before withdrawal; EDSS progression was defined as 1-point increase in EDSS score if the baseline EDSS score was < 6.0 or 0.5-point increase if the baseline EDSS score was ≥6.0 (EDSS scores could be > 5 if scores increased between screening and baseline). ^cEndpoint is missing if the patient withdrew before the first year and did not have any active T2 lesions. CI: confidence interval; EDSS: Expanded Disability Status Scale; IFN β-1a: interferon beta-1a; OR: odds ratio; SC: subcutaneously; tiw: three times weekly