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Fig. 6 | BMC Neurology

Fig. 6

From: Effect of interferon beta-1a subcutaneously three times weekly on clinical and radiological measures and no evidence of disease activity status in patients with relapsing–remitting multiple sclerosis at year 1

Fig. 6

Proportion of patients with NEDA status up to 1 year. Based on a logistic model adjusting for age (< 40 vs. ≥40 years), sex, baseline EDSS (≤3.5 vs. > 3.5), number of relapses in 2 years prior to screening, and time since MS onset. Active T2 lesions obtained at 6-month and 1-year scans were used. aNEDA defined as no relapses, no 3-month confirmed disability progression, and no active T2 lesions over 1 year; disability progression was defined as a 1-point increase in EDSS score if the baseline EDSS score was < 6.0 or 0.5-point increase if the baseline EDSS score was ≥6.0. (EDSS score could be > 5 if scores increase between screening and baseline.). bNEDA-2, defined as NEDA with relapses defined as Scripps-assessed moderate and/or severe. cNEDA-3, defined as NEDA with relapses defined as Scripps-assessed severe. EDSS: Expanded Disability Status Scale; IFN β-1a: interferon beta-1a; NEDA: no evidence of disease activity; OR: odds ratio; SC: subcutaneously; tiw: three times weekly

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