Table 2 Risk of bias judgments for included studies
Reference | Random sequence generation | Allocation concealment | Blinding of participants and personnel | Blinding of outcome assessment | Incomplete outcome data | Selective reporting | Other sources of bias |
|---|---|---|---|---|---|---|---|
ADVANCE 2014 | Low risk | Low risk | High risk | High risk | High risk | Low risk | High risk |
AVANTAGE 2014 | Unclear risk | Unclear risk | High risk | High risk | Unclear risk | Low risk | Low risk |
BECOME 2009 | Unclear risk | Unclear risk | High risk | High risk | Low risk | Low risk | High risk |
BEYOND 2009 | Low risk | Low risk | High risk | High risk | Unclear risk | Low risk | High risk |
Bornstein 1987 | Unclear risk | High risk | High risk | High risk | Low risk | Low risk | Low risk |
BRAVO 2014 | Low risk | Low risk | High risk | Low risk | Low risk | High risk | High risk |
Calabrese 2012 | Low risk | Low risk | High risk | High risk | Low risk | High risk | Low risk |
CombiRx 2013 | Low risk | Low risk | Low risk | Low risk | High risk | Low risk | Low risk |
CONFIRM 2012 | Low risk | Low risk | High risk | High risk | High risk | Low risk | High risk |
Cop1 MSSG 1995 | Unclear risk | Low risk | High risk | High risk | Low risk | Low risk | Low risk |
ECGASG 2001 | Low risk | Low risk | High risk | High risk | Low risk | Unclear risk | High risk |
Etemadifar 2006 | Unclear risk | Unclear risk | High risk | High risk | Low risk | Unclear risk | Unclear risk |
EVIDENCE 2007 | Low risk | Low risk | High risk | High risk | Low risk | Low risk | High risk |
GALA 2013 | Unclear risk | Low risk | High risk | High risk | Unclear risk | Low risk | High risk |
GATE 2015 | Low risk | Low risk | High risk | High risk | Low risk | Low risk | High risk |
IFNB MSSG 1995 | Unclear risk | Unclear risk | High risk | High risk | High risk | Low risk | High risk |
IMPROVE 2012 | Unclear risk | Low risk | Unclear risk | Unclear risk | Unclear risk | High risk | High risk |
INCOMIN 2002 | Low risk | Low risk | High risk | High risk | Low risk | Low risk | Low risk |
Kappos 2011 | Low risk | Low risk | High risk | High risk | Low risk | High risk | High risk |
Knobler 1993 | Unclear risk | Unclear risk | High risk | High risk | Unclear risk | Unclear risk | High risk |
MSCRG 1996 | Low risk | Unclear risk | Low risk | Low risk | High risk | Unclear risk | High risk |
PRISMS 1998 | Low risk | Low risk | Unclear risk | Low risk | Low risk | Low risk | High risk |
REFORMS 2012 | Low risk | Unclear risk | High risk | High risk | Unclear risk | Low risk | High risk |
REGARD 2008 | Low risk | Unclear risk | High risk | Low risk | Low risk | Low risk | High risk |