Table 2 Subgroup Analysis of Efficacy and Safety Outcomes
Efficacy outcomes | ||||||||
Complete occlusion | Recurrence in DSA | Excellent functional outcome | Good functional outcome | |||||
RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | |
1. Hydrogel coil | ||||||||
Second generation | 1.26 (1.07, 1.48) | 0.005 | 1.09 (0.98, 1.23) | 0.119 | 0.97 (0.90, 1.05) | 0.498 | 0.97 (0.92, 1.03) | 0.358 |
First generation | 1.07 (0.90, 1.25) | 0.450 | 1.04 (0.95, 1.13) | 0.390 | 0.97 (0.88, 1.06) | 0.482 | 0.97 (0.93, 1.00) | 0.074 |
2. Ruptured ratio (%) | ||||||||
N > 30 | 1.21 (1.07, 1.38) | 0.002 | 1.08 (0.99, 1.18) | 0.077 | 1.00 (0.88, 1.12) | 0.964 | 0.97 (0.92, 1.02) | 0.187 |
N < 30 | 0.99 (0.82, 1.20) | 0.938 | 1.02 (0.92, 1.18) | 0.684 | 0.95 (0.88, 1.01) | 0.116 | 0.97 (0.93, 1.01) | 0.133 |
Safety outcomes | ||||||||
Mid-term residual neck | Retreatment | Stroke | Morbidity | |||||
RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | RR (95% CI) | P value | |
3. Hydrogel coil | ||||||||
Second generation | 0.54 (0.34, 0.86) | 0.010 | 0.50 (0.20, 1.21) | 0.122 | 1.39 (0.45, 4.31) | 0.570 | 2.31 (0.61, 8.84) | 0.220 |
First generation | 0.88 (0.56, 1.39) | 0.576 | 1.08 (0.68, 1.69) | 0.752 | 0.79 (0.34, 1.87) | 0.594 | 1.03 (0.66, 1.60) | 0.899 |
4. Ruptured ratio (%) | ||||||||
N > 30 | 0.67 (0.43, 1.03) | 0.070 | 0.64 (0.33, 1.24) | 0.186 | 1.39 (0.45, 4.31) | 0.570 | 1.28 (0.79, 2.07) | 0.317 |
N < 30 | 1.15 (0.33, 4.02) | 0.827 | 1.13 (0.68, 1.88) | 0.629 | 0.79 (0.34, 1.87) | 0.594 | 0.73 (0.31, 1.69) | 0.461 |