| Normal | CW | L | L + CW | L + CW + IH | L + IH | p value |
---|---|---|---|---|---|---|---|
VTE (ml) | 134 (130.3, 173.8) | 136 (131.3, 175) | 136 (132.5, 177.5) | 138 (131.8, 176) | 136.5 (134.5, 175) | 136.5 (133.5, 175.8) | >  0.999 |
PPEAK (cm H2O) | 18.5 (14.5, 21.5) | 22 (17.5, 24.5) | 23.5 (21.5, 24.8)* | 30.5 (24.3, 32.8)* | 27 (25.3, 35.8)* | 22.5 (19.8, 25.5) | < 0.001 |
PES-EE (cm H2O) | 4.1 (4.1, 5.1) | 6.8 (5.4, 6.8)* | 5.4 (4.1, 6.5) | 7.5 (5.4, 10.2)* | 6.8 (5.8, 9.2)* | 5.4 (4.4, 5.4) | < 0.001 |
Airway resistance (cm H2O*s/L) | 21.8 (17.5, 23.3) | 21.2 (18, 27.8) | 26.9 (20.6, 31.3) | 34.9 (27.3, 39.5)* | 30.4 (22, 42.9)* | 23.2 (17.3, 30) | 0.007 |
Airway driving pressure (cm H2O) | 8.8 (6.8, 10.5) | 12.2 (9.9, 13.6)* | 13.6 (11.2, 13.6)* | 19 (12.6, 20.1)* | 15.6 (13.9, 22.8)* | 12.9 (11.2, 13.6)* | <  0.001 |
Chest wall driving pressure (cm H2O) | 2.7 (2.7, 4.1) | 6.8 (4.4, 6.8)* | 2 (1.4, 2.7) | 4.8 (2.9, 5.4) * | 6.1 (5.4, 6.8) * | 2.7 (1.4, 2.7) | < 0.001 |
Transpulmonary driving pressure (cm H2O) | 4.8 (4.1, 7.8) | 5.4 (4.4, 7.8) | 10.9 (9.5, 12.2)* | 12.2 (9.7, 16.3)* | 9.5 (8.5, 17)* | 10.9 (8.5, 10.9)* | <  0.001 |
ERS (cm H2O/L) | 57.1 (48.1, 73.1) | 79.3 (72.3, 96.4) | 86.8 (77.6, 102.6)* | 109.4 (95.4, 149.9)* | 114.6 (84.7, 164.4)* | 86.8 (78.4, 100)* | <  0.001 |
ECW (cm H2O/L) | 21.6 (20.3, 23.5) | 38.9 (32.5, 49.6)* | 13.1 (10.1, 18.6)* | 28.1 (22.2, 39.6)* | 40.3 (33, 48.1)* | 17.6 (10.3, 20.4) | < 0.001 |
EL (cm H2O/L) | 37.5 (25.3, 50.2) | 39 (31.3, 54.4) | 74.2 (63.1, 89.1)* | 84.4 (62.3, 112.9)* | 70 (52.3, 119.5)* | 65.6 (60.8, 85.7)* | 0.001 |
ECW/ERS ratio | 0.4 (0.29, 0.48) | 0.47 (0.41, 0.61)* | 0.16 (0.1, 0.22)* | 0.25 (0.21, 0.4)* | 0.34 (0.29, 0.42) | 0.21 (0.13, 0.27)* | <  0.001 |