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Table 1 Respiratory mechanics parameters at 5 cm H2O of positive end-expiratory pressure in each condition

From: Intracranial pressure responsiveness to positive end-expiratory pressure in different respiratory mechanics: a preliminary experimental study in pigs

  Normal CW L L + CW L + CW + IH L + IH p value
VTE (ml) 134 (130.3, 173.8) 136 (131.3, 175) 136 (132.5, 177.5) 138 (131.8, 176) 136.5 (134.5, 175) 136.5 (133.5, 175.8) >  0.999
PPEAK (cm H2O) 18.5 (14.5, 21.5) 22 (17.5, 24.5) 23.5 (21.5, 24.8)* 30.5 (24.3, 32.8)* 27 (25.3, 35.8)* 22.5 (19.8, 25.5) < 0.001
PES-EE (cm H2O) 4.1 (4.1, 5.1) 6.8 (5.4, 6.8)* 5.4 (4.1, 6.5) 7.5 (5.4, 10.2)* 6.8 (5.8, 9.2)* 5.4 (4.4, 5.4) < 0.001
Airway resistance (cm H2O*s/L) 21.8 (17.5, 23.3) 21.2 (18, 27.8) 26.9 (20.6, 31.3) 34.9 (27.3, 39.5)* 30.4 (22, 42.9)* 23.2 (17.3, 30) 0.007
Airway driving pressure (cm H2O) 8.8 (6.8, 10.5) 12.2 (9.9, 13.6)* 13.6 (11.2, 13.6)* 19 (12.6, 20.1)* 15.6 (13.9, 22.8)* 12.9 (11.2, 13.6)* <  0.001
Chest wall driving pressure (cm H2O) 2.7 (2.7, 4.1) 6.8 (4.4, 6.8)* 2 (1.4, 2.7) 4.8 (2.9, 5.4) * 6.1 (5.4, 6.8) * 2.7 (1.4, 2.7) < 0.001
Transpulmonary driving pressure (cm H2O) 4.8 (4.1, 7.8) 5.4 (4.4, 7.8) 10.9 (9.5, 12.2)* 12.2 (9.7, 16.3)* 9.5 (8.5, 17)* 10.9 (8.5, 10.9)* <  0.001
ERS (cm H2O/L) 57.1 (48.1, 73.1) 79.3 (72.3, 96.4) 86.8 (77.6, 102.6)* 109.4 (95.4, 149.9)* 114.6 (84.7, 164.4)* 86.8 (78.4, 100)* <  0.001
ECW (cm H2O/L) 21.6 (20.3, 23.5) 38.9 (32.5, 49.6)* 13.1 (10.1, 18.6)* 28.1 (22.2, 39.6)* 40.3 (33, 48.1)* 17.6 (10.3, 20.4) < 0.001
EL (cm H2O/L) 37.5 (25.3, 50.2) 39 (31.3, 54.4) 74.2 (63.1, 89.1)* 84.4 (62.3, 112.9)* 70 (52.3, 119.5)* 65.6 (60.8, 85.7)* 0.001
ECW/ERS ratio 0.4 (0.29, 0.48) 0.47 (0.41, 0.61)* 0.16 (0.1, 0.22)* 0.25 (0.21, 0.4)* 0.34 (0.29, 0.42) 0.21 (0.13, 0.27)* <  0.001
  1. Data are presented as median (interquartile range)
  2. *p < 0.05 compared to the Normal condition
  3. VTE expiratory tidal volume, PPEAK peak airway pressure, PES-EE end-expiratory esophageal pressure, ERS respiratory system elastance, ECW chest wall elastance, EL lung elastance