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Table 1 Respiratory mechanics parameters at 5 cm H2O of positive end-expiratory pressure in each condition

From: Intracranial pressure responsiveness to positive end-expiratory pressure in different respiratory mechanics: a preliminary experimental study in pigs

 

Normal

CW

L

L + CW

L + CW + IH

L + IH

p value

VTE (ml)

134 (130.3, 173.8)

136 (131.3, 175)

136 (132.5, 177.5)

138 (131.8, 176)

136.5 (134.5, 175)

136.5 (133.5, 175.8)

>  0.999

PPEAK (cm H2O)

18.5 (14.5, 21.5)

22 (17.5, 24.5)

23.5 (21.5, 24.8)*

30.5 (24.3, 32.8)*

27 (25.3, 35.8)*

22.5 (19.8, 25.5)

< 0.001

PES-EE (cm H2O)

4.1 (4.1, 5.1)

6.8 (5.4, 6.8)*

5.4 (4.1, 6.5)

7.5 (5.4, 10.2)*

6.8 (5.8, 9.2)*

5.4 (4.4, 5.4)

< 0.001

Airway resistance (cm H2O*s/L)

21.8 (17.5, 23.3)

21.2 (18, 27.8)

26.9 (20.6, 31.3)

34.9 (27.3, 39.5)*

30.4 (22, 42.9)*

23.2 (17.3, 30)

0.007

Airway driving pressure (cm H2O)

8.8 (6.8, 10.5)

12.2 (9.9, 13.6)*

13.6 (11.2, 13.6)*

19 (12.6, 20.1)*

15.6 (13.9, 22.8)*

12.9 (11.2, 13.6)*

<  0.001

Chest wall driving pressure (cm H2O)

2.7 (2.7, 4.1)

6.8 (4.4, 6.8)*

2 (1.4, 2.7)

4.8 (2.9, 5.4) *

6.1 (5.4, 6.8) *

2.7 (1.4, 2.7)

< 0.001

Transpulmonary driving pressure (cm H2O)

4.8 (4.1, 7.8)

5.4 (4.4, 7.8)

10.9 (9.5, 12.2)*

12.2 (9.7, 16.3)*

9.5 (8.5, 17)*

10.9 (8.5, 10.9)*

<  0.001

ERS (cm H2O/L)

57.1 (48.1, 73.1)

79.3 (72.3, 96.4)

86.8 (77.6, 102.6)*

109.4 (95.4, 149.9)*

114.6 (84.7, 164.4)*

86.8 (78.4, 100)*

<  0.001

ECW (cm H2O/L)

21.6 (20.3, 23.5)

38.9 (32.5, 49.6)*

13.1 (10.1, 18.6)*

28.1 (22.2, 39.6)*

40.3 (33, 48.1)*

17.6 (10.3, 20.4)

< 0.001

EL (cm H2O/L)

37.5 (25.3, 50.2)

39 (31.3, 54.4)

74.2 (63.1, 89.1)*

84.4 (62.3, 112.9)*

70 (52.3, 119.5)*

65.6 (60.8, 85.7)*

0.001

ECW/ERS ratio

0.4 (0.29, 0.48)

0.47 (0.41, 0.61)*

0.16 (0.1, 0.22)*

0.25 (0.21, 0.4)*

0.34 (0.29, 0.42)

0.21 (0.13, 0.27)*

<  0.001

  1. Data are presented as median (interquartile range)
  2. *p < 0.05 compared to the Normal condition
  3. VTE expiratory tidal volume, PPEAK peak airway pressure, PES-EE end-expiratory esophageal pressure, ERS respiratory system elastance, ECW chest wall elastance, EL lung elastance