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Table 1 Demographics and clinical characteristics of HIV-positive adults with new-onset seizure (n = 95)

From: Mortality & recurrent seizure risk after new-onset seizure in HIV-positive Zambian adults

Demographic

 Gender, female n (%)

41 (43)

 Age, mean (SD)

36.9 (10.2)

 Family history of epilepsy n (%)

11 (12)

 History of head injury n (%)

2 (2)

 History of severe malaria n (%)

6 (6)

 History of meningitis/encephalitis n (%)

7 (7)

 History of coma n (%)

1 (1)

 History of opportunistic infection (n = 94)a n (%)

5 (5)

 History of stroke (n = 94) a n (%)

4 (4)

Clinical

Seizure type n (%)

 Focal clonic

13 (14)

 Focal onset to bilateral tonic-clonic

33 (35)

 Tonic clonic

1 (1)

 Unknown onset bilateral tonic-clonic

42 (44)

 Unclassified

6 (6)

Presenting seizure severity n (%)b

 Status epilepticus

50 (53)

Glasgow Coma Score, mean (SD)

14.3 (1.9)

Karnofsky score < 50 at enrollment n (%)

16 (17)

WHO clinical stage n (%)a

 I or II

12 (13)

 III or IV

81 (85)

Current cART use n (%)

 Yes, less than a year

13 (14)

 Yes, more than a year

17 (18)

 No, defaulted

7 (7)

 No, never

58 (61)

CD4+ T-cell count at enrolment, mean cells/mm3(n = 89) a (SD)

179 (185)

Underlying seizure etiology c

CNS opportunistic infection n (%)

21 (22)

Other infection n (%)

8 (8)

Structural lesion n (%)

25 (26)

Hyponatremia (n = 91) n (%)

47 (49)

Likely secondary to another etiology

17/47 (36)

Unknown, n (%)

20 (21)

  1. Data is presented as number (%), mean (SD), or median (IQR), as appropriate. WHO World Health Organization, cART combination antiretroviral therapy, CNS central nervous system. aPatient unable to provide information. bMissing data for 6 participants cMore than one seizure etiology possible