Homology modeling of novel missense variants identified in TPP1 gene. The native structure (blue) and mutant structure (brown) are superimposed. a The model of p.Arg152Ser depicting the amino acid change from basic to polar at the codon number 152 (AGG-AGC). b The model of p.Tyr459Ser depicting the amino acid change from cyclic to non-cyclic at the codon number 459 (TAC-TCC). Both the models reveal the conformational changes in the TPP1 protein structure.