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Fig. 4 | BMC Neurology

Fig. 4

From: Batten disease: biochemical and molecular characterization revealing novel PPT1 and TPP1 gene mutations in Indian patients

Fig. 4

Homology modeling of novel missense variants identified in TPP1 gene. The native structure (blue) and mutant structure (brown) are superimposed. a The model of p.Arg152Ser depicting the amino acid change from basic to polar at the codon number 152 (AGG-AGC). b The model of p.Tyr459Ser depicting the amino acid change from cyclic to non-cyclic at the codon number 459 (TAC-TCC). Both the models reveal the conformational changes in the TPP1 protein structure.

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