Structural MRI correlates of PASAT performance in multiple sclerosis

BMC Neurology

Table 1 Voxel-based morphometry analysis. Multiple regression analysis showing correlations between PASAT and brain regions, using age, sex, years of education, and total intracranial volume as covariates. FDR corrected p-value < 0.05, k = 100

Brain region (Brodmann area)	MNI coordinates			T value	Z score	Cluster-level	Peak-level	K (number of voxels)
Brain region (Brodmann area)	x	y	z	T value	Z score	p-value (FWE corrected)	p-value (FDR-corrected)	K (number of voxels)
Left and right precuneus and posterior cingulate [7, 31]	−4	− 48	45	5.53	5.36	< 0.0001	0.003	5556
	4	−39	43	5.04	4.91		0.003
	18	−64	16	4.39	4.30		0.007
Right insula [13], caudate and putamen	34	2	−3	5.30	5.15	< 0.0001	0.003	3972
	40	−18	9	3.99	3.92		0.0014
	18	16	−12	3.34	3.30		0.0046
Right cerebellum (anterior and posterior lobes)	24	−57	−12	5.19	5.04	< 0.0001	0.003	2719
	24	−46	−12	5.02	4.89		0.003
	39	−58	−14	3.87	3.81		0.018
Left insula [13], caudate and putamen	−32	3	−3	4.70	4.59	< 0.0001	0.004	3548
	−27	14	1	4.24	4.16		0.009
	−22	21	3	4.19	4.11		0.010
Left cerebellum (anterior lobe)	−27	−49	−24	4.43	4.34	0.013	0.006	1375
Left thalamus	−2	−19	15	3.91	3.84	0.532	0.017	324

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