rs1234313 and rs45454293 are risk factors of cerebral arterial thrombosis, large artery atherosclerosis, and carotid plaque in the Han Chinese population: a case-control study

Table 6 The association of TNFSF4 rs1234313 and rs4545293 polymorphism with LAA and SVD in patients with ischemic stroke

Genetic model	Comparison	RRR^a vs. controls	p-value	95% CI lower	95%CI Upper
rs1234313
LAA
allelic	G vs A	0.397	0.000*	0.337	0.467
Dominant	GG/GA vs AA	0.580	0.000*	0.502	0.670
genotypic	GA vs AA	0.543	0.000*	0.455	0.650
	GG vs AA	0.228	0.000*	0.150	0.346
SVD
allelic	G vs A	0.388	0.000*	0.319	0.473
Dominant	GG/GA vs AA	0.543	0.000*	0.451	0.654
genotypic	GA vs AA	0.486	0.000*	0.383	0.616
	GG vs AA	0.241	0.000*	0.153	0.382
rs45454293
LAA
allelic	G vs A	1.087	0.000*	1.051	1.125
Dominant	GG/GA vs AA	1.011	0.131	0.997	1.025
genotypic	GA vs AA	1.026	0.643	0.920	1.144
	GG vs AA	1.014	0.089	0.998	1.031
SVD
allelic	G vs A	0.917	0.020*	0.853	0.987
Dominant	GG/GA vs AA	0.993	0.633	0.963	1.023
genotypic	GA vs AA	1.002	0.970	0.916	1.095
	GG vs AA	0.985	0.526	0.941	1.032

TNFSF4 Tumor necrosis factor super family member 4, LAA large artery atherosclerosis, SVD small vessel disease, RRR relative risk ration, CI Confidence interval; *, p < 0.05, indicating a significant difference

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