| |
Baseline (6-months pre-index date)
|
Selected Follow-up (12 months post-index)
|
|---|
|
With BD (N = 16,440)
|
Without BD (N = 86,962)
|
P Value
|
With BD (N = 11,440)
|
Without BD (N = 54,516)
|
P Value
|
|---|
|
Medical Comorbidities (%)
|
|
Hypertension
|
55.3%
|
58.0%
|
< 0.001
|
80.6%
|
77.7%
|
< 0.001
|
|
Dyslipidemia
|
23.4%
|
26.7%
|
< 0.001
|
41.2%
|
42.8%
|
0.001
|
|
Diabetes
|
24.1%
|
25.5%
|
< 0.001
|
30.8%
|
30.3%
|
0.332
|
|
Cerebrovascular disease
|
20.2%
|
21.0%
|
0.019
|
39.7%
|
34.5%
|
< 0.001
|
|
Urinary tract infection
|
17.8%
|
15.4%
|
< 0.001
|
39.6%
|
27.2%
|
< 0.001
|
|
Chronic Pulmonary Disease
|
14.4%
|
16.3%
|
< 0.001
|
25.1%
|
24.1%
|
0.021
|
|
Congestive Heart Failure
|
12.9%
|
13.7%
|
0.004
|
23.7%
|
20.9%
|
< 0.001
|
|
Peripheral vascular disease
|
8.4%
|
8.9%
|
0.068
|
18.4%
|
15.6%
|
< 0.001
|
|
Hip fracture and other fractures
|
10.1%
|
9.5%
|
0.024
|
21.1%
|
16.0%
|
< 0.001
|
|
Malignancy
|
8.0%
|
9.8%
|
< 0.001
|
11.6%
|
13.3%
|
< 0.001
|
|
Malnutrition
|
2.4%
|
2.0%
|
0.0004
|
6.1%
|
3.8%
|
< 0.001
|
|
Pneumonia
|
6.8%
|
7.1%
|
0.231
|
17.4%
|
13.3%
|
< 0.001
|
|
Psychiatric Conditions (%)
|
|
Mood disorder
|
16.7%
|
13.3%
|
< 0.001
|
41.6%
|
25.7%
|
< 0.001
|
|
Depression
|
16.0%
|
12.4%
|
< 0.001
|
40.4%
|
24.4%
|
< 0.001
|
|
Delirium
|
6.95%
|
4.57%
|
< 0.001
|
21.0%
|
9.5%
|
< 0.001
|
|
Psychotic disorders
|
19.0%
|
12.0%
|
< 0.001
|
46.7%
|
21.4%
|
< 0.001
|
|
Psychosis
|
16.1%
|
10.1%
|
< 0.001
|
39.7%
|
17.8%
|
< 0.001
|
|
Altered Mental State
|
16.9%
|
11.4%
|
< 0.001
|
43.1%
|
21.6%
|
< 0.001
|
|
Anxiety Disorder
|
9.1%
|
7.2%
|
< 0.001
|
26.1%
|
14.6%
|
< 0.001
|
- BD behavioral disturbance
