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Table 4 Associations between genotype combinations and carotid stenosis

From: The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke

Rs1131882

CC

TT

TT

TT

CT

TT

TT, CT

TT, CT

Rs1371097

CC

TT

CT, TT

CT

CT

TT

TT

TT, CT

Rs2317676

AA

GG

GG

AG

AG

AG, GG

GG

GG, AG

OR

1 a

2.76

1.99

2.11

1.06

1.14

1.17

1.05

95% CI

–

1.27–7.89

1.03–5.12

1.08–6.15

0.87–1.77

0.88–2.23

0.94–2.87

0.81–1.92

P value

–

0.002†

0.023†

0.018†

0.213‡

0.385‡

0.165‡

0.467‡

  1. aThe wild type genotype for each genetic factor was used as the reference OR. OR, odds ratio; CI, confidence intervals
  2. † high-risk interactive genotypes were defined as there were significant associations between different combination of genotypes and carotid stenosis after adjustment with confounding variables (P < 0.05)
  3. ‡ low-risk interactive genotypes were defined as there were no significant associations between different combination of genotypes and carotid stenosis after adjustment with confounding variables (P > 0.05)