The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke

Table 5 Association of high-risk interactive genotypes with platelet aggregation and platelet-leukocyte aggregates

1	Platelet aggregation (%)		Platelet-leukocyte aggregates (%)
1	AA-induced	ADP-induced	Leukocyte	Neutrophil	Monocyte	Lymphocyte
High-risk interactive genotypes †
Yes (n = 180)	89.4 ± 11.5	89.2 ± 12.3	24.9 ± 5.7	25.8 ± 5.8	27.2 ± 6.7	26.5 ± 5.4
No (n = 434)	84.3 ± 14.6	84.7 ± 13.7	22.3 ± 6.4	23.5 ± 6.2	24.1 ± 7.3	24.8 ± 6.6
P value	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001	< 0.001

AA arachidonic acid, ADP adenosine diphosphate
† high-risk interactive genotypes were defined as there were significant associations between different combination of genotypes and carotid stenosis after adjustment with confounding variables (P < 0.05)

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