The TXA2R rs1131882, P2Y1 rs1371097 and GPIIIa rs2317676 three-loci interactions may increase the risk of carotid stenosis in patients with ischemic stroke

Table 6 Multivariate analysis of the major risk factors for carotid stenosis

Risk factor	OR^a	95% CI	P value
Hypertension	1.91	1.03–4.02	0.031
Diabetes mellitus	1.77	1.02–2.92	0.039
Homocysteine	0.92	0.85–1.54	0.355
Hyperlipidemia	0.88	0.79–1.31	0.734
Hemoglobin A1c	0.93	0.85–1.37	0.546
Previous statins	0.79	0.54–1.12	0.473
Previous antiplatelet therapy	0.83	0.72–1.26	0.502
High-risk interactions	2.69	1.22–7.33	0.003

OR odds ratios, CI confidence interval
^aOR for Homocysteine, Hemoglobin A1c, Platelet aggregation and Platelet-leukocyte aggregates means per 1-Standard Deviation increase

ISSN: 1471-2377