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Fig. 3 | BMC Neurology

Fig. 3

From: Primary brain amyloidoma, both a neoplastic and a neurodegenerative disease: a case report

Fig. 3

Confocal laser-scanning micrographs of the cerebral amyloidoma. Immunoreactivity for λ-light chain monomers (A) and thioflavin S (ThS)-stained amyloid in a paraffin section (A´). The overlay in (A´´) shows that the precursors are much more disseminated than their β-pleated self aggregates (original magnification × 60). Micrograph from a frozen section with thioflavin S-stained amyloid (B), combined with Cy3-immunolabeling of GFAP in perivascular astroglia (B´) and lectin-staining with Ricinus communis agglutinin (RCA) with Cy5, color-coded in blue (B´´). The allocation of markers becomes even clearer in the merged picture (B´´´), displaying amyloid deposits in the perivascular space, within the vessel wall and the vascular lumen (original magnification × 200)

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