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Table 1 Delphi criteria for APD [10]

From: Characterizing advanced Parkinson’s disease: OBSERVE-PD observational study results of 2615 patients

Delphi consensus criteria questions Patient has
1. Troublesome motor fluctuations, severity level Moderate or severe
2. “Off” time, hours/waking day ≥ 2 or < 2
3. Nighttime sleep disturbances, severity level Moderate or severe
4. Troublesome dyskinesia, hours/waking day 2–3 or > 3
5. Non-motor fluctuations present Yes
6. “Off” time at least every 3 h Yes
7. ≥ 5 times daily oral levodopa dosing Yes
8. Activities of daily living limitation, severity level Moderate or severe
9. Falling, frequency Most of the time or all the time
10. Dementia, severity level Moderate or severe
11. Psychosis, severity level Moderate or Severe