Characterizing advanced Parkinson’s disease: OBSERVE-PD observational study results of 2615 patients

BMC Neurology

Table 4 Correlations between physician’s judgment of APD and individual Delphi criteria for APD

		Odds ratio
Prognostic parameter	Regression coefficient	Adjusted estimate	95% Wald CI		p value
Troublesome motor fluctuations (severity level, moderate/severe versus mild)	0.1122	1.119	0.743	1.684	0.5909
“Off” time (hours/waking day, ≥ 2 h versus < 2 h	0.0190	1.019	0.691	1.503	0.9235
Nighttime sleep disturbances (severity level, moderate/severe versus mild)	0.0167	1.017	0.744	1.389	0.9166
Troublesome dyskinesia (hours/waking day, ≥ 2 h versus < 2 h)	0.3610	1.435	0.827	2.490	0.1993
Non-motor fluctuations present (yes versus no)	0.1763	1.193	0.893	1.593	0.2322
“Off” time at least every 3 h (yes versus no)	0.3944	1.483	0.978	2.251	0.0638
≥ 5 times daily oral levodopa dosing (yes versus no)	0.7417	2.100	1.544	2.854	< 0.0001 ^a
Activities of daily living limitation (severity level, moderate/severe versus mild)	0.5389	1.714	1.213	2.422	0.0022 ^a
Falling (frequency, most/all the time versus some of the time)	0.0432	1.044	0.397	2.744	0.9302
Dementia (severity level, moderate/severe versus mild)	−0.4134	0.661	0.399	1.097	0.1093
Psychosis (severity level, moderate/severe versus mild)	0.5745	1.776	0.846	3.731	0.1291

^aCorrelations with physician’s judgment were significant for the Delphi criteria ≥5 times daily oral levodopa dosing (p < 0.0001) and activities of daily living limitation (p = 0.0022). APD advanced Parkinson’s disease, CI confidence interval

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