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Table 4 Correlations between physician’s judgment of APD and individual Delphi criteria for APD

From: Characterizing advanced Parkinson’s disease: OBSERVE-PD observational study results of 2615 patients

  Odds ratio
Prognostic parameter Regression coefficient Adjusted estimate 95% Wald CI p value
Troublesome motor fluctuations
(severity level, moderate/severe versus mild)
0.1122 1.119 0.743 1.684 0.5909
“Off” time
(hours/waking day, ≥ 2 h versus < 2 h
0.0190 1.019 0.691 1.503 0.9235
Nighttime sleep disturbances
(severity level, moderate/severe versus mild)
0.0167 1.017 0.744 1.389 0.9166
Troublesome dyskinesia
(hours/waking day, ≥ 2 h versus < 2 h)
0.3610 1.435 0.827 2.490 0.1993
Non-motor fluctuations present
(yes versus no)
0.1763 1.193 0.893 1.593 0.2322
“Off” time at least every 3 h
(yes versus no)
0.3944 1.483 0.978 2.251 0.0638
≥ 5 times daily oral levodopa dosing
(yes versus no)
0.7417 2.100 1.544 2.854 < 0.0001 a
Activities of daily living limitation
(severity level, moderate/severe versus mild)
0.5389 1.714 1.213 2.422 0.0022 a
Falling
(frequency, most/all the time versus some of the time)
0.0432 1.044 0.397 2.744 0.9302
Dementia
(severity level, moderate/severe versus mild)
−0.4134 0.661 0.399 1.097 0.1093
Psychosis
(severity level, moderate/severe versus mild)
0.5745 1.776 0.846 3.731 0.1291
  1. aCorrelations with physician’s judgment were significant for the Delphi criteria ≥5 times daily oral levodopa dosing (p < 0.0001) and activities of daily living limitation (p = 0.0022). APD advanced Parkinson’s disease, CI confidence interval