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Table 4 Effect size of BUN/Cr on HT in prespecified and exploratory subgroups

From: Effects of the blood urea nitrogen to creatinine ratio on haemorrhagic transformation in AIS patients with diabetes mellitus

Characteristic

No of participants

Effect size(95%CI), p value

P for interaction

BUN/Cr

0.02*

 < 30.71

1644

1.04 (1.00, 1.07), 0.04

 

 30.71

89

0.91 (0.80, 1.03), 0.15

 

Age (year)

0.22

 < 65

910

1.01 (0.98, 1.05), 0.51

 

 ≧65

823

1.04 (1.01, 1.07), 0.01

 

Sex

0.89

 Female

689

1.02 (0.99, 1.05), 0.11

 

 Male

1044

1.03 (0.99, 1.07), 0.19

 

Hypertention

0.49

 No

873

1.03 (1.00, 1.06), 0.03

 

 Yes

860

1.02 (0.98, 1.05), 0.41

 

Diabetes Mellitus

0.04*

 No

1415

1.01 (0.99, 1.04), 0.39

 

 Yes

318

1.07 (1.02, 1.12), < 0.01

 

Hyperlipidemia

0.15

 No

1651

1.03 (1.01, 1.05), 0.02

 

 Yes

82

0.87 (0.68, 1.12), 0.29

 

Atrial Fibrillation

0.86

 No

1599

1.02 (1.00, 1.05), 0.05

 

 Yes

134

1.03 (0.96, 1.10), 0.40

 

Alcohol intake

0.32

 No

1288

1.02 (1.00, 1.05), 0.09

 

 Yes

445

1.05 (0.99, 1.12), 0.07

 

Current smoking

0.77

 No

1129

1.02 (1.00, 1.05), 0.07

 

 Yes

604

1.03 (0.98, 1.08), 0.19

 

Stroke severity

0.48

 No

1543

1.03 (1.01, 1.05), 0.02

 

 Yes

190

1.01 (0.96, 1.06), 0.69

 

Blood platelet

0.49

 No

864

1.03 (1.00, 1.06), 0.03

 

 Yes

869

1.02 (0.98, 1.05), 0.30

 

Albumin

0.31

 No

861

1.02 (0.99,1.04), 0.29

 

 Yes

873

1.04 (1.00, 1.08), 0.03

 

Triglyceride

0.24

 Low

867

1.01 (0.99, 1.04), 0.33

 

 High

866

1.04 (1.01, 1.08), 0.02

 

Total cholesterol

0.74

 Low

866

1.02 (1.00, 1.05), 0.09

 

 High

867

1.03 (0.99, 1.07), 0.11

 

HDL

0.59

 Low

855

1.02 (0.99, 1.05), 0.23

 

 High

878

1.03 (1.00, 1.06), 0.04

 

LDL

0.93

 Low

865

1.02 (1.00, 1.05), 0.06

 

 High

868

1.03 (0.99, 1.07), 0.18

 
  1. BUN Blood urea nitrogen, Cr Creatinine, HDL High-density lipoprotein, LDL Low-density lipoprotein
  2. Note 1: Above model adjusted for Age; Blood platelet; Albumin; Stroke severity; Triglyceride; LDL
  3. Note 2:In each case, the model is not adjusted for the stratification variable