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Table 1 Profiles of the ALS cases examined in this study

From: Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study

 

Discontinued

Continued

P value

n

20

72

 

Sex (male, n, %)

12, 60

34, 47.2

0.31

Age (Median, IQR, years old)

64.5 (58.3–72.8)

62.5 (56.5–69.3)

0.35

Initial symptom, n

Muscle weakness: 19

Muscle weakness: 70

 

Muscle cramp: 1

Muscle cramp: 1

 
 

FTD: 1

 

Onset site of weakness (n, %)

B: 5, 25.0

B: 23, 31.9

0.4

C: 9, 45.0

C: 23, 31.9

0.5

T: 0, 0

T: 2, 2.8

0.5

L:6, 30.0

L: 22, 30.6

0.63

FTD (n, %)

5, 20

10, 12.5

0.77

  1. B bulbar, C cervical, FTD Frontotemporal dementia, L lumbar, T: thoracic, P values are obtained by the Wald chi-square test, based on the null hypothesis that the characteristic contributes to the discontinuation more than the other reasons in the discontinued group. P value of age is obtained by t-test, compared discontinued group with continued group
  2. No patient characteristics were significantly associated with drug discontinuation