Interstitial pneumonia and other adverse events in riluzole-administered amyotrophic lateral sclerosis patients: a retrospective observational study

Table 4 The course of biochemical analyses data of case1 with elevated liver enzymes

	AST	ALT	ALP	γ-GTP	LDH	T-Bil
Before riluzole treatment	21	25	189	15	187	0.8
When abnormality occurred	50	88	259	17	213	0.7
The worst biochemical data	65	132	238	37	229	0.8
After discontinuation	25	37	259	21	175	0.6

ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, γ-GTP gamma-glutamyl transpeptidase, T-bil total bilirubin
T-bil: mg/dL, Others: U/L
Biochemical analysis at day 30 of riluzole treatment revealed elevated AST from 21 to 50 U/L and elevated ALT from 25 to 88 U/L. The liver enzyme levels worsened at 1 month after drug discontinuation but gradually improved; the symptom disappeared within 2 months after riluzole discontinuation

ISSN: 1471-2377