Table 1 Clinical and biochemical characteristics of Wilson’s disease patients with corpus callosum abnormalities and without corpus callosum abnormalities
From: Characteristics of neurological Wilson’s disease with corpus callosum abnormalities
WD-no-CCA | WD-CCA | P value | |
|---|---|---|---|
Gender(male/female) | 23/9 | 6/3 | 1.00 |
Age of onset | 17.4 ± 6.1 years | 17.8 ± 3.8 years | 0.87 |
From onset to corpus callosum abnormal | – | 9.2 ± 4.8 years | – |
Course of the disease | 3.4 ± 3.6 years | 9.9 ± 4.0 years | 0.00 |
UWDRS Neurological symptoms score | 37.6 (35–38) | 65.9 (64–68) | 0.00 |
UWDRS Hepatic symptoms score | 5.7 (2–12) | 5.8 (3–11) | 0.47 |
UWDRS Psychiatric symptoms score | 11.2 (9–14) | 22.5 (20–25) | 0.00 |
Total bilirubin (μmol/L) | 14.6 ± 6.3 | 12.0 ± 5.0 | 0.26 |
Direct bilirubin (μmol/L) | 4.0 ± 1.9 | 4.6 ± 2.7 | 0.44 |
Serum albumin (g/L) | 43.6 ± 4.3 | 43.4 ± 2.8 | 0.89 |
Serum globulin (g/L) | 25.0 ± 4.4 | 27.0 ± 5.4 | 0.26 |
Alanine aminotransferase (U/L) | 27.5 ± 10.7 | 22.3 ± 7.2 | 0.45 |
Aspartate aminotransferase (U/L) | 28.9 ± 14.3 | 21.6 ± 9.9 | 0.16 |
24-h urinary copper (μg) | 213.0 ± 167.2 | 296.0 ± 115.1 | 0.18 |
Serum ceruloplasmin (μg/mL) | 73.1 ± 40.8 | 49.0 ± 13.7 | 0.09 |
Serum copper (μmol/L) | 3.5 ± 2.5 | 3.7 ± 1.2 | 0.76 |
K-F ring | 32 (100%) | 9 (100%) | – |