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Table 3 Changes in clinical assessments and vascular responses (in perfusion units) to acetylcholine and sodium nitroprusside in responders and non-responders, and the subsequent time course of decay in acetylcholine response to 50% of the peak value at baseline and following 6 months of treatment. Values are means ± SE

From: Peripheral vascular responses to acetylcholine as a predictive tool for response to cholinesterase inhibitors in Alzheimer’s disease

  Non responder Responder
Baseline 6 months Baseline 6 months
Clinical parameters
 MMSE 23.4 ± 1.0 23.0 ± 0.9 24.4 ± 0.6 25.9 ± 0.6
 NOSGER IADL/SB 39.0 ± 2.2 35.9 ± 2.6* 36.8 ± 2.4 38.8 ± 2.2
 NOSGER Total 121.8 ± 4.8 116.2 ± 4.7 116.5 ± 5.5 120.7 ± 4.7
 DSST 16.6 ± 3.7 14.5 ± 3.8* 22.3 ± 2.5 25.1 ± 1.8
Vascular responses
 Basal perfusion (PU) 49 ± 12 51 ± 13 41 ± 10 43 ± 11
 Peak acetylcholine response (PU) 345 ± 77 361 ± 49 326 ± 43 409 ± 43**
 Peak sodium nitroprusside response (PU) 288 ± 68 296 ± 45 265 ± 36 366 ± 50***
 Acetylcholine 50% decay (secs) 400 ± 60 321 ± 32 230 ± 38¥ 332 ± 42*
  1. * P < 0.05; ** P < 0.01; *** P < 0.005, comparing values at baseline versus 6 months within the two groups
  2. ¥ P < 0.05 comparing baseline acetylcholine 50% decay between non-responders and responders