Table 2 Association of SNPs of candidate genes and odds ratio to ET risk (ET without RLS)
From: IL1B polymorphism is associated with essential tremor in Chinese population
Gene | SNP | HWE p value | MAF (case/control) | Allele | ||||
Minor allele | OR | 95%CI | p | |||||
HMOX1 | rs2071746 | 0.701 | 0.44/0.46 | A | 0.90 | (0.69, 1.18) | 0.452 | |
HMOX2 | rs4786504 | 0.031 | – | – | – | – | – | |
rs1051308 | 0.983 | 0.37/0.37 | G | 1.00 | (0.75, 1.32) | 0.983 | ||
VDR | rs731236 | 0.255 | 0.07/0.05 | C | 1.47 | (0.81, 2.65) | 0.203 | |
IL17A | rs8193036 | 0.735 | 0.30/0.30 | T | 1.04 | (0.77, 1.39) | 0.809 | |
IL1B | rs1143643 | 0.591 | 0.46/0.43 | G | 1.13 | (0.86, 1.48) | 0.389 | |
rs1143634 | 0.431 | 0.04/0.02 | T | 1.64 | (0.72, 3.75) | 0.232 | ||
rs1143633 | 0.272 | 0.38/0.34 | G | 1.22 | (0.92, 1.61) | 0.171 | ||
NOS1 | rs693534 | 0.910 | 0.27/0.27 | A | 1.03 | (0.76, 1.40) | 0.858 | |
rs7977109 | 0.828 | 0.22/0.23 | G | 0.96 | (0.69, 1.32) | 0.781 | ||
ADH1B | rs6413413 | – | – | – | – | – | – | |
rs1229984 | 0.729 | 0.33/0.32 | G | 1.07 | (0.80, 1.43) | 0.644 | ||
Gene | SNP | Dominant Model (adjusted) | Recessive Model (adjusted) | Genetic Power | ||||
OR | 95%CI | p | OR | 95%CI | p | |||
HMOX1 | rs2071746 | 0.86 | (0.56, 1.32) | 0.503 | 0.90 | (0.55, 1.47) | 0.671 | 0.084 |
HMOX2 | rs4786504 | – | – | – | – | – | – | – |
rs1051308 | 0.93 | (0.62, 1.37) | 0.701 | 1.09 | (0.61, 1.96) | 0.762 | 0.050 | |
VDR | rs731236 | 1.51 | (0.82, 2.80) | 0.188 | – | – | – | 0.394 |
IL17A | rs8193036 | 0.98 | (0.66, 1.44) | 0.909 | 1.22 | (0.64, 2.34) | 0.549 | 0.053 |
IL1B | rs1143643 | 0.87 | (0.57, 1.33) | 0.516 | 1.86 | (1.12, 3.11) | 0.017 | 0.095 |
rs1143634 | 1.68 | (0.71, 3.96) | 0.234 | – | – | – | 0.629 | |
rs1143633 | 1.01 | (0.68, 1.50) | 0.948 | 2.57 | (1.38, 4.81) | 0.003 | 0.127 | |
NOS1 | rs693534 | 0.96 | (0.65, 1.41) | 0.829 | 1.33 | (0.63, 2.82) | 0.455 | 0.051 |
rs7977109 | 0.98 | (0.66, 1.46) | 0.938 | 0.74 | (0.29, 1.86) | 0.519 | 0.054 | |
ADH1B | rs6413413 | – | – | – | – | – | – | – |
rs1229984 | 0.99 | (0.67, 1.46) | 0.946 | 1.58 | (0.76, 3.25) | 0.219 | 0.063 | |