Table 2 Study characteristics
From: Evaluation of QoL in neurofibromatosis patients: a systematic review and meta-analysis study
First author (references) | Year | Country | Age (M ± SD) | Number participant | QoL measure | Type of NF/group | Physical function case/control (M ± SD) | Role physical | Bodily pain | Vitality | Mental health | Role emotiona | Social functioning | General health | Family cohesion | |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Case | Control | |||||||||||||||
Page. PZ [19] | 2006 | United States | 43 ± 11.7 | 166 | 154 | SF-36 | 1/Adult | 78 ± 26 84 ± 22 | 70 ± 41 84 ± 22 | 63 ± 27 77 ± 23 | 47 ± 25 59 ± 21 | 63 ± 19 74 ± 23 | 70 ± 38 84 ± 22 | 74 ± 25 84 ± 22 | 55 ± 25 72 ± 23 | – |
Kodra. Y [20] | 2009 | Italy | 37.7 ± 122 | 129 | 1909 | SF-36 | 1/Adult | 79 ± 26 86 ± 23 | 75 ± 34 80 ± 35 | 69 ± 27 75 ± 25 | 60 ± 20 63 ± 22 | 64 ± 21 67 ± 20 |  |  |  |  |
Merker. VL [21] | 2016 | United States | 13 | 8 | Â | SF-36 | 2/Children | 54/8 52/7 | 53/6 52/3 | 56 50/9 | 53/5 50/3 | 49/9 49/4 | 52/7 51/2 | 49 50/6 | 49/8 51/2 | Â |
Vardarinos. A [22] | 2009 | Greece | 10/1 ± 3 | 43 | 61 | CHQ–PF50 | 2/Children | 94/2 ± 16/7 94/6 ± 7/3 | 91/1 ± 22/8 97 ± 15/2 | 84/4 ± 19/5 94/9 ± 10/3 | 77/7 ± 18 83/1 ± 14/1 |  |  |  | 63/7 ± 19/4 79/8 ± 13/9 | 76/4 ± 22 83/1 ± 15/3 |
Ostenbrink. R [23] | 2007 | Netherlands | 4 ± 1/5 | 34 | 410 | IT-QOL | 1/children | 88/9 ± 20/3 97/2 ± 9/8 |  | 86 ± 15/9 83/8 ± 16/8 |  |  |  |  | 65/5 ± 16/5 79 ± 14/5 | 80/1 ± 22/1 75/3 ± 18/8 |
Wolkenstein. P [24] | 2001 | France |  | 128 | 3656 | SF-36 | 1/adult | 76/8 ± 26/4 84/5 ± 21/1 | 72/8 ± 39/1 81/3 ± 32/2 | 65/3 ± 29/6 73/5 ± 23/7 | 49/7 ± 21/3 60/1 ± 18/1 | 56/4 ± 22 68/5 ± 17/6 | 69/4 ± 39/4 82/2 ± 32/2 | 70/4 ± 25/7 81/6 ± 21/4 | 58/4 ± 23 69/2 ± 18/6 |  |
Hornigold. RE [25] | 2015 | UK | 44 | 61 | 30 | SF-36 | 2/Adult | 57/4 ± 32/9 87/99 ± 19/65 | 51/5 ± 45/3 87/17 ± 22/01 | 67/3 ± 29 78/8 ± 23/01 | 49/2 ± 27/5 58/04 ± 19/6 | 61/84 ± 26/7 71/92 ± 18/15 | 59/3 ± 45/8 85/75 ± 21/18 | 64/7 ± 33/3 82/77 ± 23/24 | 48/7 ± 31/1 71/06 ± 20/43 |  |
Krab. LC [26] | 2008 | Netherlands | 12/2 ± 2/5 | 43 | 54 | CHQ | 1/children | 95/7 ± 8/9 96/8 ± 5/4 | 96/1 ± 11/3 96/5 ± 11/6 | 71/4 ± 27/5 78/2 ± 19/5 |  | 79/8 ± 12/8 78/2 ± 13 | 92 ± 14/4 92/3 ± 16/8 |  | 72/7 ± 16/2 74/6 ± 15/9 | 75/6 ± 26/7 75/7 ± 23/1 |
Hornigold. RE [27] | 2012 | UK | 41 | 50 | 30 | SF-36 | 2/Adult | 57/4 ± 33/9 84/25 ± 29/19 | 51/5 ± 46/53 83/85 ± 23/89 | 67/3 ± 29/94 81/1 ± 17/05 | 49/2 ± 28/4 62/6 ± 15/38 | 61/84 ± 29/16 74/5 ± 12/02 | 59/3 ± 47/23 82/65 ± 13/28 | 64/7 ± 33/91 88/2 ± 11/74 | 48/7 ± 31/74 73/05 ± 14/4 |  |
Merker. VL [28] | 2014 | United state | 38/7 ± 14/5 39/7 ± 29/7 | 142/53 | 50/50 | SF-36 | 1,2/Adult | 49/2 46/1 49/2 49/2 | 48 44/5 46/6 46/6 | 50/9 50/3 46/1 46/1 | 50/3 47/8 49/1 49/1 | 46/5 48 49/2 49/2 | 46/2 47/4 47/9 47/9 | 48/7 45 48/1 48/1 | 48/6 42/8 47/5 47/5 |  |