BMC Neurology

Table 1 Spearman correlation coefficients of each CSF protein level with patient background and motor symptoms

From: Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

	Patient background				Motor symptoms
		Age	Education	Duration from symptom onset	UPDRS part III	Tremor	Rigidity	Bradykinesia	Gait	Postural instability
Total αS	r	0.362	0.216	−0.314	− 0.446^*	0.192	− 0.331	− 0.528^**	− 0.245	−0.356
	p	0.0635	0.2794	0.1104	0.0289	0.3692	0.1136	0.0080	0.2482	0.0873
	n	27	27	27	24	24	24	24	24	24
O-αS	r	0.010	−0.036	0.203	−0.205	0.265	− 0.119	−0.224	− 0.335	−0.310
	p	0.9614	0.8594	0.3105	0.3356	0.2101	0.5792	0.2928	0.1095	0.1407
	n	27	27	27	24	24	24	24	24	24
Aβ1–42	r	0.292	0.131	−0.231	−0.085	0.140	−0.024	−0.107	− 0.160	−0.047
	p	0.1389	0.5150	0.2473	0.6913	0.5141	0.9104	0.6203	0.4546	0.8283
	n	27	27	27	24	24	24	24	24	24
Total tau	r	0.334	0.180	−0.212	−0.297	0.002	−0.195	−0.426^*	− 0.167	−0.163
	p	0.0886	0.3702	0.2877	0.1581	0.9934	0.3610	0.0379	0.4346	0.4457
	n	27	27	27	24	24	24	24	24	24
P-tau181p	r	0.491^*	0.081	−0.032	−0.448^*	0.029	−0.425^*	−0.462^*	− 0.048	−0.338
	p	0.0126	0.7004	0.8804	0.0365	0.8978	0.0486	0.0303	0.8317	0.1241
	n	25	25	25	22	22	22	22	22	22

*: p < 0.05, **: p < 0.01
Abbreviations: Total αS, Total α-synuclein; O-αS, Oligomeric α-synuclein; P-tau181p, tau phosphorylated at threonine 181; UPDRS Unified Parkinson’s Disease Rating Scale

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ISSN: 1471-2377

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