BMC Neurology

Table 2 Spearman correlation coefficients of each CSF protein level with cognitive assessment scores

From: Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

Battery		MoCA	COGNISTAT
Subtests		Total score	Orientation	Attention	Language-comprehension	Language-repetition	Language-naming	Construction	Memory	Calculation	Similarity	Judgement
Total αS	r	0.204	0.176	−0.119	0.174	0.168	0.447	0.345	0.158	0.245	0.088	0.626^**
	p	0.3385	0.4706	0.6275	0.4770	0.4914	0.0551	0.1475	0.5171	0.3117	0.7213	0.0041
	n	24	19	19	19	19	19	19	19	19	19	19
O-αS	r	0.227	0.190	−0.161	0.171	0.146	−0.196	0.137	0.095	0.087	0.139	0.244
	p	0.2871	0.4354	0.5091	0.4833	0.5500	0.4216	0.5747	0.6992	0.7220	0.5711	0.3135
	n	24	19	19	19	19	19	19	19	19	19	19
Aβ1–42	r	0.426^*	0.145	0.085	0.176	0.057	0.079	0.371	0.290	0.103	0.048	0.432
	p	0.0379	0.5530	0.7298	0.4706	0.8159	0.7493	0.1175	0.2285	0.6739	0.8441	0.0651
	n	24	19	19	19	19	19	19	19	19	19	19
Total tau	r	0.053	0.088	−0.227	0.111	0.268	0.461^*	0.302	−0.030	0.288	0.116	0.547^*
	p	0.8056	0.7199	0.3502	0.6514	0.2671	0.0469	0.2094	0.9016	0.2314	0.6365	0.0155
	n	24	19	19	19	19	19	19	19	19	19	19
P-tau181p	r	−0.292	0.051	−0.234	−0.287	−0.065	0.112	−0.054	− 0.294	−0.327	− 0.403	0.280
	p	0.1877	0.8459	0.3660	0.2635	0.8047	0.6678	0.8365	0.2516	0.2005	0.1085	0.2759
	n	22	17	17	17	17	17	17	17	17	17	17

*: p < 0.05, **: p < 0.01
Abbreviations: Total αS, Total α-synuclein; O-αS, Oligomeric α-synuclein; P-tau181p, tau phosphorylated at threonine 181; MoCA, the Montreal Cognitive Assessment; COGNISTAT, the Neurobehavioral Cognitive Status Examination

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ISSN: 1471-2377

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