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Table 2 Spearman correlation coefficients of each CSF protein level with cognitive assessment scores

From: Correlated levels of cerebrospinal fluid pathogenic proteins in drug-naïve Parkinson’s disease

Battery   MoCA COGNISTAT          
Subtests   Total score Orientation Attention Language-comprehension Language-repetition Language-naming Construction Memory Calculation Similarity Judgement
Total αS r 0.204 0.176 −0.119 0.174 0.168 0.447 0.345 0.158 0.245 0.088 0.626**
  p 0.3385 0.4706 0.6275 0.4770 0.4914 0.0551 0.1475 0.5171 0.3117 0.7213 0.0041
  n 24 19 19 19 19 19 19 19 19 19 19
O-αS r 0.227 0.190 −0.161 0.171 0.146 −0.196 0.137 0.095 0.087 0.139 0.244
  p 0.2871 0.4354 0.5091 0.4833 0.5500 0.4216 0.5747 0.6992 0.7220 0.5711 0.3135
  n 24 19 19 19 19 19 19 19 19 19 19
Aβ1–42 r 0.426* 0.145 0.085 0.176 0.057 0.079 0.371 0.290 0.103 0.048 0.432
  p 0.0379 0.5530 0.7298 0.4706 0.8159 0.7493 0.1175 0.2285 0.6739 0.8441 0.0651
  n 24 19 19 19 19 19 19 19 19 19 19
Total tau r 0.053 0.088 −0.227 0.111 0.268 0.461* 0.302 −0.030 0.288 0.116 0.547*
  p 0.8056 0.7199 0.3502 0.6514 0.2671 0.0469 0.2094 0.9016 0.2314 0.6365 0.0155
  n 24 19 19 19 19 19 19 19 19 19 19
P-tau181p r −0.292 0.051 −0.234 −0.287 −0.065 0.112 −0.054 − 0.294 −0.327 − 0.403 0.280
  p 0.1877 0.8459 0.3660 0.2635 0.8047 0.6678 0.8365 0.2516 0.2005 0.1085 0.2759
  n 22 17 17 17 17 17 17 17 17 17 17
  1. *: p < 0.05, **: p < 0.01
  2. Abbreviations: Total αS, Total α-synuclein; O-αS, Oligomeric α-synuclein; P-tau181p, tau phosphorylated at threonine 181; MoCA, the Montreal Cognitive Assessment; COGNISTAT, the Neurobehavioral Cognitive Status Examination