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Table 1 Management of side effects

From: An update on Peginterferon beta-1a Management in Multiple Sclerosis: results from an interdisciplinary Board of German and Austrian Neurologists and dermatologists

Strategies for the management of skin reactions
 • Patients should receive a detailed introduction on injection echniques and precautions to avoid cutaneous adverse events.
 • Warming the interferon solution to room temperature before injection.
 • Usage of an aseptic injection technique.
 • Rotation of the subcutaneous injection site at each injection.
In the case of injection site erythema
 • Cold black-tea compresses can be applied for anti-inflammatory effects and cooling.
 • To reduce pruritus and erythema, topic treatment with 5% polidocanol may be applied.
 • Topical corticosteroids with appropriate therapeutic index in case of more severe erythema and eczema, palpable, infiltrated lesions, are e.g. prednicarbate (group II), mometasone (group III).
 • In order to achieve an additional itch-relief effect, lotions, creams and ointments can be stored in the refrigerator under hygienic conditions.
Strategies for the management of FLS
 • Patients should be informed about the possibility of the occurrence and precautions to avoid or reduce FLS.
 • Gradual titration of the (Peg)interferon beta dose at the initiation of treatment according to the product information has been shown to significantly ameliorate symptoms.
 • Prophylactic and concurrent use of anti-inflammatory, analgesic and/or antipyretic treatments such as acetaminophen, ibuprofen, or naproxen may prevent or ameliorate FLSs.
 • Optimal timing of injection should be determined individually.