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Fig. 2 | BMC Neurology

Fig. 2

From: Pathological findings in a patient with non-dystrophic myotonia with a mutation of the SCN4A gene; a case report

Fig. 2

a-d HE staining. Variation in diameter of muscle fibers including hypertrophy (over 100 μm) and atrophy was observed (a). Internal nuclei, chained nuclei (b), fiber splitting (c), pyknotic nuclear clumps (d), endomysial fibrosis and mild fatty replacement were observed in all areas. e modified Gomori trichrome staining. Ragged-red fibers could not be observed but fibers exhibiting slight marginal hyperstaining were observed. f NADH-TR(β-nicotinamide adenine dinucleotide tetrazolium reductase)staining. Disorganized intermyofibrillar networks including a moth-eaten appearance and lobulated fibers could be seen. g Myosin ATPase staining. Reduction of type 2B fibers and predominancy of type 2A fibers could be seen

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BMC Neurology

ISSN: 1471-2377

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