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Table 1 Comparison of pathological findings between DM1, DM2 and the present case

From: Pathological findings in a patient with non-dystrophic myotonia with a mutation of the SCN4A gene; a case report

  Present case DM1 DM2 NDMs
Fiber size variation ++ +++ +++ +
Endomysial fibrosis + +++ ++ ±
Increase of internal nuclei +++ +++ +++ ±
Pyknotic nuclear clumps + + +++
Sarcoplasmic masses ++ ±
Chained nuclei + + unknown
Fiber splitting + + unknown
Ragged red fibers + ±
Fiber type predominancy 2A > 1> > 2B type1 type1 2A > 1> > 2B
Type of atrophy nonspecific type1 > type2 type2 type2B
Ring fibers ++ ±
Fatty replacement + +++ ++
  1. +++ severe; ++ modest; + mild; ±occasionally present; − absent