Fig. 2

Sera from asymptomatic and symptomatic ATTRv patients exhibit altered immune response. Serum from 28 patients diagnosed positive for ATTRv and 24 age- and sex-matched healthy subjects were collected, and nine different cytokines and immune system associated-molecules were measured: IL-8 (a), IL-33 (b), IL-1β (c), TNF-α (d), IL-10 (e), IL-12 (f), IFN-β (g), IL-6 (h) and cortisol (i). ATTRv patients were scored by Coutinho index (12) and separated by aggressiveness: FAP 0 = asymptomatic; FAP 1 = mild symptoms; FAP 2–3 = moderate to aggressive symptoms. Data were analyzed using unpaired one-way ANOVA followed by Kruskal-Wallis test. *p < 0.05, **p < 0.01 and ***p < 0.001