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Table 1 Comparison of clinical profiles between controls and patients with severe extracranial carotid artery stenosis (CAS)

From: Metabolomics study in severe extracranial carotid artery stenosis

 

Group

Control

CAS

p value

n = 65

n = 65

Age (years)

61.3 ± 5.2

63.2 ± 5.7

0.050

Male, n (%)

65 (100)

65 (100)

 

Ischemic stroke, n (%)

0 (0)

63 (97.0)

< 0.001

Coronary artery disease, n (%)

4 (6.2)

19 (29.2)

< 0.001

Risk factor profile

 Hypertension, n (%)

25 (38.5)

48 (73.8)

< 0.001

 Atrial fibrillation, n (%)

0 (0)

0 (0)

 

 Smoking, n (%)

25 (38.5)

52 (80.0)

< 0.001

 Alcohol, n (%)

14 (22.5)

26 (40.0)

0.039

 Hx of recurrent stroke, n (%)

0 (0)

18 (27.7)

< 0.001

 Body mass index (kg/m2)

25.7 ± 7.0

24.6 ± 6.0

0.058

Laboratory blood test

 Homocysteine (mg/dL)

10.3 ± 4.0

12.9 ± 7.8

0.011

 HS-CRP (mg/dL)

2.5 ± 5.8

3.2 ± 3.3

0.446

 Total Cholesterol (mg/dL)

209.1 ± 43.2

178.9 ± 50.5

< 0.001

 Triglyceride (mg/dL)

146.5 ± 78.0

135.5 ± 77.6

0.418

 LDL-C (mg/dL)

123.2 ± 41.8

112.5 ± 38.8

0.105

 HDL-C (mg/dL)

48.0 ± 13.2

38.9 ± 10.9

< 0.001

 Serum sodium (mEq/L)

141.2 ± 47.0

140.3 ± 68.3

0.219

 Hemoglobin (g/dL)

14.7 ± 7.4

13.7 ± 5.9

0.018

 AC sugar (mg/dL)

100.7 ± 36.6

97.6 ± 49.4

0.304

 Uric acid (mg/dL)

6.6 ± 1.9

6.3 ± 2.3

0.358

 eGFR (ml/min/1.73 m2)

75.2 ± 28.1

84.0 ± 46.3

0.319

  1. Patients with diabetes are excluded from the study. LDL-C low density lipoprotein-cholesterol, HDL-C high density lipoprotein-cholesterol, eGFR estimated glomerular filtration rate