Biomarkers of immune capacity, infection and inflammation are associated with poor outcome and mortality after stroke - the PREDICT study

Table 1 Baseline characteristics stratified according to outcome after 3 months^e

Characteristic	All	mRS 0–2	mRS 3–6	p-value
n (%)	391	231	160
Female Sex, n (%)	165 (42.2)	83 (35.9)	82 (51.3)	0.003 ^a
Age, yrs., mean (SD)	70 (12)	67 (12)	75 (10)	< 0.001 ^b
NIHSS categories, n (%)12 missing				< 0.001 ^d
0–4	217 (57.3)	156 (69.6)	61 (39.4)
5–15	140 (36.9)	64 (28.6)	76 (49.0)
16+	22 (5.8)	4 (1.8)	18 (11.6)
Pneumonia, n (%)	20 (5.1)	0 (0)	20 (12.5)	< 0.001 ^a
Comorbidities, n (%)
Hypertension (13 missing)	313 (82.8)	179 (79.9)	134 (87.0)	0.072 ^a
Diabetes mellitus	98 (26.3)	45 (20.5)	53 (34.6)	0.002 ^a
Atrial Fibrillation (18 missing)	113 (30.3)	53 (24.1)	60 (39.2)	0.002 ^a
Hypercholesterolemia (18 missing)	192 (51.5)	112 (50.2)	80 (53.3)	0.556 ^a
Previous stroke (18 missing)	75 (20.1)	41 (18.6)	34 (22.2)	0.395 ^a
mHLA-DR day 1 (pg/ml)
Median (IQR) (4 missing)	16,422 [12268–21,990]	17,871 [13703–232,270]	15,062 [11340–19,333]	< 0.001 ^c
IL-6 day 1 (pg/ml)
Median (IQR)(10 missing)	4.3 [2.3–8.5]	3.6 [2.0–6.8]	5.5 [3.4–11.4]	< 0.001 ^c
IL-10 day 1 (pg/ml)
Median (IQR) (12 missing)	5.0 [5.0–5.0]	5.0 [5.0–5.0]	5.0 [5.0–5.0]	0.113 ^c
LBP day 1 (pg/ml)
Median (IQR) (11 missing)	7.5 [5.8–9.5]	7.0 [5.5–8.8]	8.2 [6.3–10.9]	< 0.001 ^c
TNF-α day 1 (pg/ml)
Median (IQR) (16 missing)	631 [459–887]	609 [452–868]	673 [462–898]	0.343 ^c

^aPearson Chi-square test, ^b t-Test for unequal variance, ^c Mann-Whitney Test, ^d Chi-square test linear by linear
^eAnalyses were restricted to patients without missing values for mRS after 3 months or death within the study period and the respective variable
IQR = Q2-Q3